肌萎缩侧索硬化相关免疫细胞的研究进展

doi:10.11958/20230187

天津医药 ›› 2023, Vol. 51 ›› Issue (7): 697-700.doi: 10.11958/20230187

所属专题：专题研究

• 专题研究·肌萎缩侧索硬化 • 上一篇下一篇

肌萎缩侧索硬化相关免疫细胞的研究进展

苏博洋¹^,²(), 何正卿¹^,², 黄旭升¹^,²^,^△()

1 解放军医学院（邮编100853）
2 解放军总医院第一医学中心神经内科

收稿日期:2022-02-15 修回日期:2022-03-08 出版日期:2023-07-15 发布日期:2023-06-20
通讯作者: ^△黄旭升 E-mail:lewish301@sina.com
作者简介:苏博洋（1998），女，硕士在读，主要从事运动神经元病方面研究。E-mail：731895496@qq.com

Research progress of amyotrophic lateral sclerosis related immune cells

SU Boyang¹^,²(), HE Zhengqing¹^,², HUANG Xusheng¹^,²^,^△()

1 Chinese PLA Medical School, Beijing 100853, China
2 Department of Neurology, the First Medical Center, Chinese PLA General Hospital

Received:2022-02-15 Revised:2022-03-08 Published:2023-07-15 Online:2023-06-20
Contact: ^△HUANG Xusheng E-mail:lewish301@sina.com

苏博洋, 何正卿, 黄旭升. 肌萎缩侧索硬化相关免疫细胞的研究进展[J]. 天津医药, 2023, 51(7): 697-700.

SU Boyang, HE Zhengqing, HUANG Xusheng. Research progress of amyotrophic lateral sclerosis related immune cells[J]. Tianjin Medical Journal, 2023, 51(7): 697-700.

摘要/Abstract

摘要：

肌萎缩侧索硬化（ALS）是一种神经系统退行性疾病，其发病机制包括谷氨酸兴奋毒性、氧化应激损伤、神经丝异常聚集、细胞内钙异常聚集、神经营养因子缺乏、线粒体功能障碍、RNA代谢紊乱、免疫功能障碍等因素。就单核细胞/巨噬细胞、自然杀伤细胞、星型胶质细胞、小胶质细胞、CD4^＋T细胞、CD8^＋T细胞、调节性T细胞的数量和功能对ALS的影响进行综述。

关键词: 肌萎缩侧索硬化, 免疫细胞, 免疫应答

Abstract:

Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, and its pathogenesis includes glutamate excitotoxicity, oxidative stress injury, abnormal aggregation of neurofilaments, abnormal aggregation of intracellular calcium, neurotrophic factor deficiency, mitochondrial dysfunction, RNA metabolism disorder and immune dysfunction. This article reviews the effects of monocytes/macrophages, natural killer cells, astrocytes, microglia, CD4⁺T cells, CD8⁺ T cells and the number and function of regulatory T cells on ALS.

Key words: amyotrophic lateral sclerosis, immune cell, immune response

中图分类号:

R746.4

参考文献 34

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肌萎缩侧索硬化相关免疫细胞的研究进展

Research progress of amyotrophic lateral sclerosis related immune cells

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