天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (5): 566-569.doi: 10.11958/j.issn.0253-9896.2015.05.030

• 综述 • 上一篇    下一篇

长链非编码RNA与乳腺癌侵袭转移相关性研究进展

苏薇， 张瑾△#br# #br#   

  1. 天津医科大学肿瘤医院乳腺肿瘤三科 （邮编300060）； 国家肿瘤临床医学研究中心； 天津市乳腺癌防治研究中心； 天津市肿瘤防治重点实验室； 乳腺癌防治教育部重点实验室
  • 收稿日期:2014-10-11 修回日期:2014-11-09 出版日期:2015-05-15 发布日期:2015-05-25
  • 通讯作者: 张瑾,E-mail: zhangjin@tjmuch.com E-mail:zhangjin@tjmuch.com
  • 作者简介:苏薇 （1988）， 女， 硕士在读， 主要从事乳腺肿瘤研究
  • 基金资助:
    天津市重大科技专项 （工程） 项目资助(12ZCDZSY15700)

Progress in correlation of long non-coding RNA with breast cancer invasion and metastasis

SU Wei, ZHANG Jin△   

  1. The 3rd Department of Breast Cancer Tianjin Medical University Cancer Institute and Hospital; National Clinical Research Center of Cancer, Tianjin 300060, China; Tianjin Breast Cancer Prevention, Treatment and Research Center; Key laboratory of breast cancer prevention and therapy; Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 30060, China
  • Received:2014-10-11 Revised:2014-11-09 Published:2015-05-15 Online:2015-05-25
  • Contact: ZHANG Jin,E-mail: zhangjin@tjmuch.com E-mail:zhangjin@tjmuch.com
  • Supported by:
    Tianjin municipal Major Scientific and Technological Special Project for Significant Anticancer Development

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摘要： 摘要： 长链非编码 RNA（lncRNA）是一类长度大于 200 nt， 不具备编码蛋白质能力的功能性 RNA 分子。研究发现， lncRNA 的异常表达与乳腺癌的进展关系密切， 部分 lncRNA 参与调控乳腺癌侵袭转移的过程。本文对乳腺癌中异常表达的 lncRNA 及其与乳腺癌侵袭转移的相关性进行综述， 以期为乳腺癌的诊疗提供新的思路。

关键词: 侵袭, 转移长链非编码 RNA, 乳腺癌, 肿瘤侵润, 肿瘤转移, 分子标志物, 综述

Abstract: Abstract:Long non-coding RNA(lncRNA) is a group of functional RNA molecules, which is more than 200 nucleotides in length and lacks ability of encoding protein. The current study indicates that the abnormal expression of lncRNA is closely related with breast cancer progression. Some lncRNA takes part in regulating the process of breast cancer invasion and me⁃ tastasis. This article reviews the abnormal expression of lncRNA in breast cancer and the relevance with breast cancer inva⁃ sion and metastasis, which is expected to provide new strategy for breast cancer diagnosis and treatment.

Key words: lncRNA, breast cancer, neoplasm invasiveness, neoplasm metastasis, molecular marker, review