天津医药 ›› 2015, Vol. 43 ›› Issue (5): 570-572.doi: 10.11958/j.issn.0253-9896.2015.05.031

• 综述 • 上一篇    下一篇

口腔癌相关microRNA研究进展

刘晓楠, 张文超△#br# #br#   

  1. 天津医科大学肿瘤医院、 国家肿瘤临床医学研究中心、 天津市 “肿瘤防治” 重点实验室 (邮编300060)
  • 收稿日期:2014-09-23 修回日期:2014-11-25 出版日期:2015-05-15 发布日期:2015-05-25
  • 通讯作者: 张文超,E-mail: zwbeyond_999@sina.com E-mail:liuxiaonan8812@126.com
  • 作者简介:刘晓楠(1988), 女,硕士在读, 主要从事头颈部肿瘤研究
  • 基金资助:
    天津市卫生局科技基金资助项目 (2011kz75)

Research advances of microRNA related to oral cancer

LIU Xiaonan , ZHANG Wenchao△   

  1. Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer & Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060
  • Received:2014-09-23 Revised:2014-11-25 Published:2015-05-15 Online:2015-05-25
  • Contact: ZHANG Wenchao,E-mail: zwbeyond_999@sina.com E-mail:liuxiaonan8812@126.com

摘要: 口腔癌是常见的头颈部恶性肿瘤, 局部复发及转移是其预后差的主要因素, 但具体分子机制尚不清楚。研究发现, 微小 RNA(microRNA)在口腔癌的发生、 侵袭、 转移中起到重要作用, 有望成为有价值的诊断标志物和治疗靶点。本文就口腔癌相关 microRNA 的研究进展进行综述。

关键词: 口腔癌, 微小RNA, 进展, 治疗, 预后

Abstract: Oral cancer is a common cancer of head and neck. Regional recurrence and metastasis are the main course of the poor prognosis. But the exact molecular mechanism is still unknown. Studies have showed that microRNA plays an im⁃ portant role in the tumorigenesis, invasion and metastasis of oral cancer. And it is expected to become a valuable diagnostic marker and therapeutic target. This paper makes a review about the microRNA related to oral cancer.

Key words: oral cancer, microRNA, progression, therapy, prognosis