天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (7): 762-765.doi: 10.11958/j.issn.0253-9896.2015.07.017

• 临床研究 • 上一篇    下一篇

血清25OHD水平与精液参数的关系

贾新转，魏兰   

  1. 河北医科大学第四医院生殖医学科

  • 收稿日期:2014-12-25 修回日期:2015-01-25 出版日期:2015-07-15 发布日期:2015-07-15
  • 通讯作者: 魏兰 E-mail:1134979643@qq.com

The Associations of Serum 25OHD Levels with Semen Parameters

JIA Xinzhuan, WEI Lan   

  1. No.4 Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011,China

  • Received:2014-12-25 Revised:2015-01-25 Published:2015-07-15 Online:2015-07-15
  • Contact: WEI Lan E-mail:1134979643@qq.com

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摘要： 目的 探讨血清25羟维生素D(25OHD)水平与精液参数之间的关系。方法 测定68例健康男性血清25OHD水平，将其分为25OHD正常组22例(30 μg/L≤25OHD<40 μg/L)、25OHD相对不足组20例(20 μg/L≤25OHD<30 μg/L)和25OHD缺乏组26例(25OHD<20 μg/L)。采用化学发光免疫分析法测定血清生殖激素，包括卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、泌乳素(PRL)、睾酮(T)。禁欲3~7 d后手淫法获取精液标本，应用精子质量分析仪检测精子总数、精子浓度、精子前向运动百分率、精子正常形态百分率。结果 3组FSH、LH、E2、PRL、T水平差异无统计学意义，且均在正常值范围。25OHD相对不足组和25OHD缺乏组精子总数、精子浓度、精子前向运动百分率、精子正常形态百分率均低于25OHD正常组；25OHD缺乏组精子总数、精子前向运动百分率低于25OHD相对不足组（均P<0.05），精子浓度、精子正常形态百分率与25OHD相对不足组差异无统计学意义。结论 精液质量降低可能与血清25OHD相对不足或缺乏有关。25OHD对精子参数的影响，可能不是由生殖激素所介导。

关键词: 维生素 D,  精子,  血清,  25 羟维生素 D,  精液参数

Abstract: Abstract: Objective To analyze the relationship between serum 25 hydroxy vitamin D (25OHD) levels and semen pa⁃
rameters. Methods The serum levels of 25OHD were examined in 68 healthy men, who were divided into three groups.
Twenty-two cases were included in 25OHD normal group (30 μg/L≤25OHD<40 μg/L), 20 cases were in 25OHD relatively
insufficient group (20 μg/L≤25OHD<30 μg/L), and 26 cases were in 25OHD deficiency group (25OHD<20 μg/L). The se⁃
rum reproductive hormones including follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E 2), prolactin
(PRL) and testosterone (T) were detected by chemiluminescence immune analysis. Semen samples were collected by mastur⁃
bation after a period of abstinence for 3 and 7 days. The total sperm count, sperm concentration, percentage of progressive
motile sperm and percentage of normal morphology sperm were measured by sperm quality analyzer. Results There were
no significant differences in FSH, LH, E2, PRL and T levels between three groups, and which were all in normal ranges. The
total sperm count, sperm concentration, percentage of progressive motile sperm and percentage of normal morphology sperm
were significantly lower in 25OHD relatively insufficient group and 25OHD deficiency group than those in 25OHD normal
group. The total sperm count and the percentage of progressive motile sperm were significantly lower in 25OHD deficiency
group than those in 25OHD relatively insufficient group (P < 0.05). There were no statistical differences in sperm concentra⁃
tion and percentage of normal morphology sperm between 25OHD deficiency group and 25OHD relatively insufficient group.
Conclusion The decrease of semen quality may be related to serum 25OHD at the relatively insufficient and deficiency lev⁃
els. The effect of 25OHD on semen parameters may not be mediated by reproductive hormones.

Key words: vitamin D, spermatozoa, serum, 25OHD, semen parameters