天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (8): 899-901.doi: 10.11958/j.issn.0253-9896.2015.08.019

• 应用研究 • 上一篇    下一篇

IL-6 和C 反应蛋白与房颤患者左房血栓和重度左房超声自发性显影的关系

郑金国，何永辉，邓新桃，石桂良，潘闽   

  1. 1江苏省扬州大学医学院附属兴化市人民医院ICU（邮编225700）；2南通大学附属医院心内科
  • 收稿日期:2014-07-25 修回日期:2015-02-12 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 潘闽 E-mail:panminmd@163.com
  • 作者简介:郑金国（1975），男，硕士，主要从事分子心脏病学研究
  • 基金资助:
    江苏省“六大人才高峰”项目资助（2009046）

Correlation of interleukin-6 and C-reactive protien levels with left atrial thrombus and severe spontaneous echocontrast in atrial fibrillation patients

ZHENG Jinguo, HE Yonghui, DENG Xintao, SHI Guiliang, PAN Min   

  1. 1 ICU, People′s Hospital of Xinghua City, Jiangsu 225700, China; 2 Department of Cardiology, Affiliated Hospital of Nantong University
  • Received:2014-07-25 Revised:2015-02-12 Published:2015-08-15 Online:2015-08-15
  • Contact: Min Pan E-mail:panminmd@163.com

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摘要： 目的研究白细胞介素6（IL-6）、C 反应蛋白（CRP）与心房颤动（房颤）患者左房血栓和重度左房超声自发显影（SEC）的关系。方法76 例房颤患者进行病例对照研究。经食管超声心动图检查，按是否合并心房血栓分为研究组（31 例）与对照组（45 例）。检测2 组患者血清IL-6、CRP 水平。结果研究组或者重度SEC 的房颤患者血清IL-6 分别为（324.13±42.86）ng/L 和（332.29±53.17）ng/L、CRP 分别为（66.97±17.65）mg/L 和（71.81±20.19）mg/L，含量明显高于对照组或无重度SEC 的房颤患者[IL-6：（108.75±25.43）ng/L 和（93.59±27.82）ng/L；CRP：（17.28±6.52）mg/L 和（16.76±8.73）mg/L]，差异有统计学意义（P＜0.05）。结论炎症因子IL-6、CRP 的血清浓度增高，机体的高炎症状态可能和房颤患者的左心房血栓形成以及重度SEC 有关。

关键词: 白细胞介素-6, C 反应蛋白, 心房颤动, 左房血栓

Abstract: Objective To investigate the correlation of serum interleukin-6 (IL-6) and C-reactive protien (CRP) lev⁃ els with left atrial thrombus and severe spontaneous echocontrast (SEC) in patients with atrial fibrillation (AF). Methods A case-control study of patients with atrial fibrillation (n=76) was carried out. All patients were divided into control group (n= 45) and study group (n=31) according to their conventional echocardiography performance. Serum IL-6 and CRP were exam⁃ ined in both groups. Results The levels of serum IL-6 in patients with thrombus and severe SEC were (324.13±42.86) ng/L and (332.29±53.17) ng/L, respectivly which is higher than that in patient without thrombus or without severe SEC (108.75± 25.43) ng/L and (93.59±27.82) ng/L respectively. In parallel, CRP levels in patients of thrombus and severe SEC were (66.97±17.65) mg/L and (71.81±20.19) mg/L respectively which is higher than that in patients without thrombus or without severe SEC (17.28±6.52) mg/L and (16.76±8.73) mg/L respectively. All differences were of statistically significant(P＜0.05). Conclusion Increase of serum IL-6 and CRP as well as high systemic inflammatory state correlate with left atrial thombus and severe SEC in patients with AF.

Key words: interleukin-6, C-reactive protien, atrial fibrillation, left atrial thombus