天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (10): 1187-1190.doi: 10.11958/j.issn.0253-9896.2015.10.027

• 应用研究 • 上一篇    下一篇

生物活性玻璃促进早期釉质龋再矿化最适浓度的研究

  

  1. 华北理工大学口腔医学院 （邮编 063000）
  • 收稿日期:2015-04-13 修回日期:2015-05-11 出版日期:2015-10-15 发布日期:2015-10-22

Optimizing concentration of bioactive glass that promotes early enamel caries remineralization#br#

  1. College of Stomatology,North China University of Science and Technology,Tangshan 063000, China
  • Received:2015-04-13 Revised:2015-05-11 Published:2015-10-15 Online:2015-10-22

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摘要： 摘要： 目的 探讨生物活性玻璃促进早期釉质龋再矿化的最适浓度。方法 收集新鲜拔除的牛切牙， 制备釉质
标本， 随机分成显微硬度组和荧光组两大组， 每组又分为 3%、 6%和 9%小组， 每小组 5 个标本。所有标本放在 37 ℃
人工脱矿液中脱矿 72 h 后， 分别浸泡在质量分数为 3%、 6%和 9%生物活性玻璃溶液内， 5 min/次， 2 次/d， 循环 15 d。
显微硬度仪测量脱矿前后及再矿化后牙釉质表面的显微硬度， 并计算再矿化前后的显微硬度差值。荧光显微镜观
察早期釉质龋表层下的荧光带厚度， 从而评价再矿化效果。结果 6%组的显微硬度差值最高， 3%组的差值最低， 差
异均有统计学意义 （均 P < 0.05）。6%组脱矿深度差值大于 3%和 9%组 （均 P < 0.05）， 3%和 9%组的脱矿深度差值差
异无统计学意义。结论 质量分数为 6%的生物活性玻璃溶液是促进早期釉质龋再矿化的最适浓度， 对早期釉质龋
再矿化效果最理想。

关键词: 龋齿, 牙釉质, 牙再矿化, 早期釉质龋, 生物活性玻璃, 显微硬度

Abstract:

Abstract: Objective To explore the optimum concentration of bioactive glass that promotes early enamel caries
remineralization. Methods Fresh bovine incisors were selected and used for enamel specimen preparation. All specimens
were randomly divided into two groups: micro hardness group and fluorescence group. Both groups were further divided into
3%, 6% and 9% groups. These specimens were placed in containers with demineralization liquid at 37 ℃ for 72 hours. Then
they were treat with 3%, 6% and 9% bioactive glass solution respectively twice a day for 5 minutes each. Samples in all three
groups were dipped circularly into an artificial demineralization solution and an artificial saliva solution for 15 days. The mi⁃
crohardness of enamel surface was measured before and after demineralization and remineralization. The different value of
microhardness before and after remineralization was calculated. The thickness of fluorescence beneath the surface of early
enamel caries was observed to evaluate the extend of remineralization effect. Results The difference in value of micro hard⁃
ness in 6% group was the highest while that in 3% group was the lowest. The differences were significant. The difference in
value of demineralization depth in 6% group was greater than those in 3% and 9% groups (P < 0.05). There was no statistical⁃
ly significance between those in 3% group and 9% group. Conclution The optimum concentration of bioactive glass solu⁃
tion that promotes the remineralization of early enamel caries is 6%, which is ideal for remineralization of early enamel caries.

Key words: dental caries, dental enamel, tooth remineralization, early enamel caries, bioactive glass, microhardness