天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (12): 1433-1436.doi: 10.11958/j.issn.0253-9896.2015.12.023

• 临床研究 • 上一篇    下一篇

饮酒量与糖尿病前期3 年转归关系的前瞻性研究

车晓礼1,2，万沁1△   

  1. 1泸州医学院附属医院内分泌代谢科（邮编646000）；2内江市第二人民医院内分泌科
  • 收稿日期:2015-04-01 修回日期:2015-06-28 出版日期:2015-12-15 发布日期:2015-12-11
  • 通讯作者: △通讯作者E-mail：wanqin3@163.com E-mail:cxli336699@163.com
  • 作者简介:车晓礼（1987），女，硕士在读，主要从事糖尿病大血管并发症研究
  • 基金资助:
    中华医学会临床医学科研专项基金-施贵宝内分泌糖尿病研究项目（12020160276）

A prospective study of the relationship between alcohol consumption and outcome of three-year pre-diabetes

CHE Xiaoli1,2，WAN Qin1△   

  1. 1 Department of Endocrinology, the Affiliated Hospital of Luzhou Medical College，Luzhou，Sichuan 646000，China； 2 Department of Endocrinology, the Second People′s Hospital of Neijiang
  • Received:2015-04-01 Revised:2015-06-28 Published:2015-12-15 Online:2015-12-11
  • Contact: △Corresponding Author E-mail：wanqin3@163.com E-mail:cxli336699@163.com

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摘要： 目的探讨饮酒量与糖尿病前期3 年转归的关系。方法研究对象来自泸州地区2 型糖尿病患者肿瘤发生风险的流行病学研究，从基线调查中筛选出糖尿病前期人群1 125 例。按饮酒量分为不饮、少量、中量和大量饮酒4 组，按体质指数（BMI）是否大于24 kg/m2 分2 组。对所调查对象进行3 年随访。比较不同饮酒量和BMI 水平糖尿病发生情况。结果完成随访1 116 例，失访9 例。不饮、少量、中量和大量饮酒组糖尿病发病率分别为18.81%、 8.80%、16.51%、26.53%。Cox 比例风险回归分析显示，调整性别、年龄、BMI、热量、基线血糖因素后，少、中、大量饮酒组与不饮酒组糖尿病发病相对风险比RR 及95%CI 分别为0.49（0.31～0.79）、1.15（0.69～1.92）、1.95（1.25～3.04）。按BMI 分组比较：BMI＜24 kg/m2 人群少、中、大量饮酒组与不饮酒组糖尿病发病风险比RR 及95%CI 分别为：0.40 （0.20～0.80）、0.77（0.30～1.97）、1.10（0.46～2.64）；BMI≥24 kg/m2 人群少、中、大量饮酒组与不饮酒组糖尿病发病风险比RR 及95%CI 分别为：0.62（0.33～1.66）、1.49（0.80～2.80）、2.64（1.55～4.47）。结论少量饮酒可以降低BMI＜ 24 kg/m2糖尿病前期人群的糖尿病发病风险，对于BMI≥24 kg/m2 人群大量饮酒则增加糖尿病发病风险。

关键词: 饮酒, 糖尿病前期, 发病率, 前瞻性研究, 随访研究

Abstract: Objective To investigate the associations of alcohol consumption with the outcome of three-year pre-dia⁃ betes. Methods The objects of this study were selected from the epidemiological study of cancer risk of Chinese patients with type 2 diabetes mellitus (T2DM) in Luzhou area. A total of 1 125 cases with pre-diabetes were selected from the base⁃ line survey. Patients divided into four groups including non-alcohol drinking group, small alcohol drinking group, moderate alcohol drinking group, and large alcohol drinking group. Patients also were divided into two groups according to body mass index (BMI, more than 24 kg/m2). The patients were followed up for three years. The incidence rates of diabetes mellitus were compared between different drinking groups and different BMI groups. Results A total of 1 116 cases were completed the follow-up , 9 cases were lost to follow-up. The incidence rates of DM were 18.81%, 8.80%, 16.51% and 26.53% for non-al⁃ cohol drinking group, small alcohol drinking group, moderate alcohol drinking group, and large alcohol drinking group. Cox proportional hazard regression analysis showed that the relative risk ratios and 95%CI of the gender, age, BMI, calorie, base⁃ line blood glucose were 0.49 (0.31-0.79), 1.15 (0.69-1.92) and 1.95 (1.25-3.04) for small alcohol drinking group, moderate alcohol drinking group, and large alcohol drinking group. In the group of BMI < 24 kg/m2，the relative risks and 95%CI were 0.40 (0.20-0.80)，0.77 (0.30-1.97) and 1.10 (0.46-2.64) for small alcohol drinking group, moderate alcohol drinking group, and large alcohol drinking group. In the group of BMI≥24 kg/m2, the relative risks and 95%CI were 0.62 (0.33-1.66)，1.49 (0.80-2.80) and 2.64 (1.55-4.47). Conclusion Small amount of alcohol drinking can reduce the incidence of DM in predia⁃ betes people with BMI<24 kg/m2. Large amount of alcohol drinking is the risk factor of incidence of DM in people with BMI≥ 24 kg/m2.

Key words: alcohol drinking, prediabetic state, incidence, prospective studies, follow-up studies