天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (8): 963-966.doi: 10.11958/20160079

• 专题研究-心血管 • 上一篇    下一篇

40岁以上人群肱踝脉搏波传导速度与心脑血管事件关系的前瞻性研究

赵胜仙， 彭年春△， 时立新， 张巧， 胡颖， 徐淑静， 张淼， 张松   

  1. 贵州医科大学附属医院内分泌代谢病科 （邮编550004）
  • 收稿日期:2016-02-29 修回日期:2016-05-18 出版日期:2016-08-15 发布日期:2016-08-22
  • 通讯作者: 彭年春 E-mail： pnch2001@126.com E-mail:pnch2001@126.com
  • 作者简介:赵胜仙 （1987）， 女， 硕士在读， 主要从事内分泌与代谢病方面研究
  • 基金资助:
    中华医学会临床医学科研专项资金项目 （12020130273）

A prospective study of brachial ankle pulse wave velocity and the incidence of cardio-cerebral events in people aged over 40

ZHAO Shengxian, PENG Nianchun△, SHI Lixin, ZHANG Qiao, HU Ying, XU Shujing, ZHANG Miao, ZHANG Song   

  1. Endocrinology Department of the Affiliated Hospital of Guizhou Medical University, Guizhou 550004, China
  • Received:2016-02-29 Revised:2016-05-18 Published:2016-08-15 Online:2016-08-22
  • Contact: PENG Nianchun E-mail： pnch2001@126.com E-mail:pnch2001@126.com

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摘要： 摘要： 目的 探讨 40 岁以上人群肱踝脉搏波传导速度 （ba-PWV） 与心脑血管事件发生风险的关系。方法 2011 年 5 月—8 月， 采用整群抽样法对贵阳市云岩区 4 380 例 40 岁以上常住居民进行前瞻性研究， 检测该人群的 ba-PWV 并收集基线资料， 剔除不符合条件及患心脑血管疾病者， 将 4 189 例无心脑血管疾病的人群作为本研究的基线样本， 于2014年7月—11月对该人群进行随访。根据ba-PWV 值将将最终完成随访的3 241例分为3组： ＜14 m/s 组 （正常组， 1 039 例）、 14～17.9 m/s 组 （1 393 例）、 ≥18 m/s 组 （809 例）。应用多因素 Logistic 回归模型分析 ba- PWV 与心脑血管事件发生风险的关系。结果 3 年后发生心脑血管事件共 63 例 （2.0%）， 正常组、 14～17.9 m/s 组、 ≥18 m/s 组心脑血管事件发生率分别为 0.6%、 2.2%、 3.2%， ba-PWV 升高的两组均高于正常组， 差异有统计学意义。Logistic 回归分析显示， 调整年龄、 性别、 收缩压、 糖尿病、 高血压、 血脂异常等危险因素后， 14～17.9 m/s 组、 ≥18 m/s 组发生心脑血管事件风险比是正常组的 2.777 （1.123～6.864） 倍、 2.786 （1.032～7.526） 倍。结论 40 岁以上人群中， ba-PWV 升高组心脑血管事件发生率较高， ba-PWV 可以预测心脑血管事件的发生风险。

关键词: 脉搏, 心血管系统, 前瞻性研究, 随访研究, 肱踝脉搏波传导速度, 心脑血管事件

Abstract: Abstract: Objective To investigate the relationship between brachial ankle pulse wave velocity and the incidence of cardio-cerebral events in people aged over 40. Methods Cluster sampling method was used to prospectively study 4 380 residents aged over 40 in Guiyang City District from May to August in 2011. Data of ba-PWV were collected. The follow-up examination was conducted from July to November of 2014. According to ba-PWV values, participants were divided into three groups: <14 m/s (control, n=1 039) group, 14-17.9 m/s group (n=1 393) and ≥18 m/s group (n=809). Multi-factor Logistic regression model was used to analyze the relationship between ba-PWV values and risk factors of cardio-cerebral events. Results After three-year follow-up, a total of 3 241 participants were included in the final analysis. The cardio-cerebral events were identified in 63 (2.0%) cases, which were 0.6%, 2.2% and 3.2% in control group, 14-17.9 m/s group and ≥18 m/s group. The value of ba-PWV increased significantly in those two groups compared with that of normal group. Logistic regression analysis showed that the incidence rates of cardiovascular and cerebralvascular events in 14-17.9 m/s group and ≥18 m/s group were 2.777 (1.123-6.864) and 2.786 (1.032-7.526) times of control group after adjusting age, gender, systolic blood pressure, risk factors of diabetes, hypertension and blood lipids. Conclusion There is higher incidence rate of cardio-cerebral events in people aged over 40 in higher ba-PWV group. The value of Ba-PWV can be used to predict the occurrence of cardio-cerebral events.

Key words:  pulse, cardiovascular system, prospective studies, follow-up studies, brachial ankle pulse wave velocity, cardio-cerebral events