天津医药 ›› 2014, Vol. 42 ›› Issue (12): 1237-1239.doi: 10.3969/j.issn.0253-9896.2014.12.024

• 应用研究 • 上一篇    下一篇

维持性血液透析患者左室肥厚的相关因素分析

李春红   

  1. 天津市第三中心医院
  • 收稿日期:2013-12-16 修回日期:2014-08-19 出版日期:2014-12-15 发布日期:2014-12-15
  • 通讯作者: 李春红 E-mail:337217501@qq.com

Chun-hong LI   

  1. Nephrology Department, the Third Central Hospital of Tianjin, Tianjin 300170, China
  • Received:2013-12-16 Revised:2014-08-19 Published:2014-12-15 Online:2014-12-15
  • Contact: Chun-hong LI E-mail:337217501@qq.com

摘要:

【摘要】 目的 探讨维持性血液透析(MHD)患者左室肥厚的影响因素。 方法 对本透析中心 60 例维持性血液透析患者, 行心脏彩超检查了解左心室肥厚(LVH)情况, 60 例患者中, 共有 43 例(71.7%)患者存在 LVH(LVH 组), 17 例为非 LVH 患者(非 LVH 组)。 收集 2 组临床资料并进行血红蛋白(HGB)、血肌酐(Cr)、甲状旁腺素(iPTH)、白蛋白(ALB)、三酰甘油(TG)、胆固醇(CHO)、钙(Ca)、磷(P)、晚期氧化蛋白产物(AOPP)、C 反应蛋白(CRP)指标检测。 结果 与非 LVH 组相比, LVH 组年龄、收缩压、iPTH、AOPP 水平均明显升高(P< 0.05), BMI 及其他生化指标差异均无统计学意义。 左室心肌质量指数(LVMI)与年龄、收缩压、iPTH、AOPP 呈正相关(r 分别为 0.240、0.293、0.288 和 0.363), 与其他指标均无相关性。 多重线性回归分析显示, 收缩压、 iPTH、 AOPP 是 LVMI 的影响因素。 结论 LVH 在 MHD 患者多发, 收缩压、iPTH 和 AOPP 在 LVH 发病中起重要作用。

关键词: 肾透析, 肥大, 左心室, 血压, 甲状旁腺素, 维持性血液透析, 晚期氧化蛋白产物

Abstract:

[Abstract] Objective To explore potential related factors of left ventricular hypertrophy in maintenance hemodialy? sis (MHD) patients. Methods Sixty patients were enrolled in the study. Echocardiography was performed to exam LVH in? dexes. There are forty-three patients with LVH (LVH group), and seventeen patients without LVH (non-LVH group). Clini? cal data were collected to exam the levels of hemoglobin (HGB), creatinine (Cr), parathyrin (iPTH), albumin (ALB), triglycer? ide (TG), cholesterol(CHO), calcium(Ca), phosphorus(P), advanced oxygen protein products (AOPP) and C reactive protein (CRP). Results Compared with non-LVH group, age, BP, iPTH, AOPP were higher in LVH group patients while BMI and other biochemistry index does not show any statistical difference. Multiple linear stepwise regressions analysis shows that SBP, iPTH and AOPP are correlated factors to left ventricle mass index (LVMI). Conclusion LVH is prevalent in MHD pa? tients. BP, iPTH and AOPP are the risk factors for LVH.

Key words: renal dialysis, hypertrophy, left ventricular, blood pressure, parathyroid hormone, maintenance hemodialysis, advanced oxygen protein products