天津医药

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子痫前期患者血浆氧化低密度脂蛋白、内皮素-1及一氧化氮水平的变化及意义

许群星1,张立军2,韩玉环1   

  1. 1. 天津医科大学第二医院产科
    2. 天津医大二院妇产科
  • 收稿日期:2009-12-28 修回日期:2010-05-30 出版日期:2010-10-15 发布日期:2010-10-15
  • 通讯作者: 许群星

The Clinical Significance of Oxidized Low-Density Lipoprotein,Endothelin-1 and Nitric Oxide in Pregnant Woman With Pre-eclampsia

  • Received:2009-12-28 Revised:2010-05-30 Published:2010-10-15 Online:2010-10-15

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2007

摘要： 目的: 探讨子痫前期患者血浆氧化低密度脂蛋白、内皮素-1及一氧化氮的水平变化及临床意义。方法:选择2008年5月至2009年1月在天津医科大学第二医院产科住院治疗后分娩的孕妇39例，其中轻度子痫前期组20例，重度子痫前期组19例。选择同期住院正常晚期妊娠妇女20例为对照组。采用酶联免疫吸附试验检测各组孕妇血浆中oxLDL、ET-1水平，采用硝酸还原法检测各组孕妇血浆中NO的水平，并行相关性分析。结果:（1）轻度及重度子痫前期组孕妇血浆oxLDL水平分别为(10.06±3.61) mg/L、(13.25±3.15 )mg/L均显著高于对照组(3.77±0.71)mg/L（均P﹤0.01）。（2）正常妊娠组孕妇血浆中oxLDL、ET-1及NO水平分别为（3.77±0.71 ）mg/L、（1.15±0.35）ng/L、(58.4±9.80) μmol/L。oxLDL水平与ET-1、NO及收缩压、舒张压均无显著相关性（均P＞0.05）。（3） 轻度子痫前期组血浆oxLDL、ET-1及NO水平分别为(10.06±3.61)mg/L、(2.47±0.73)ng/L、(34.8±5.70)μmol/L。oxLDL水平与ET-1、NO水平呈显著的相关性（r分别为0.572和0.619，均P﹤0.01）；与收缩压、舒张压呈显著相关性（r分别为0.516和0.691，均P﹤0.01）。（4）重度子痫前期组血浆中oxLDL、ET-1及NO水平分别为(13.25±3.15) mg/L、(3.19±0.67)ng/L、(25.1±3.80)μmol/L。oxLDL水平与ET-1、NO水平呈显著的负相关（r分别为-0.529和-0.598，均P﹤0.01）；与收缩压、舒张压呈显著正相关（r分别为0.474和0.537，均P﹤0.01）。结论：oxLDL可通过影响血管内皮收缩舒张因子ET-1及NO的表达来参与子痫前期的病理生理过程，与子痫前期的发病密切相关。

关键词: 子痫前期, 氧化低密度脂蛋白, 内皮素-1, 一氧化氮

Abstract: Objective: To investigate the clinical significance of oxidized low-density lipoprotein, endothelin-1 and nitric oxide in pregnant woman with pre-eclampsia.Methods: From June 2008 to January 2009 ,59 woman with hypertension who delivered in the department of Obstetrics, The Second Hospital of Tianjin Medical University, were recruited,including 20 women with mild pre-eclampsia.(MPE group) and 19 women with severe pre-eclampsia.(SPE group).and 20 healthy pregnant women were taken as control group. Enzyme –linked immunosorbent assay（ELISA）was used to measure the oxLDL and ET-1 level in these women. Nitrate reduction was used to measure the NO level in the plasma and investigate the correlation of them. Results: the oxLDL level in MPE group (10.06±3.61)mg/L, SPE group (13.25±3.15)mg/L,were significantly higher compared with control group (3.77±0.71)mg/L (both P﹤0.01).(2) the plasma concentrations of oxLDL 、ET-1 and NO in healthy pregnant women group were (3.77±0.71)mg/L、(1.15±0.35)ng/L、(58.4±9.80)μmol/L. the oxLDL level has no obvious correlation with ET-1、NO、SBP and DBP（all P＞0.05）.(3) the plasma concentrations of oxLDL 、ET-1 and NO in mild pre-eclampsia. (MPE group) were (10.06±3.61)mg/L、(2.47±0.73)ng/L、(34.8±5.70)μmol/L。the oxLDL level has obvious correlation with ET-1 and NO (r=0.572、0.619, both P﹤0.01）. the oxLDL level has obvious correlation with SBP and DBP (r=0.516、0.691,both P<0.01). (4) the plasma concentrations of oxLDL、ET-1 and NO in severe pre-eclampsia(SPE group) were (13.25±3.15)mg/L、(3.19±0.67)ng/L、(25.1±3.80)μmol/L. the oxLDL level has obvious correlation with ET-1、NO、SBP and DBP(r=-0.529、-0.598、0.474、0.537，all P<0.01).Conclusion : oxLDL in plasma may be involved in the pathophysiological processes of pre-eclampsia by affecting the endothelial systolic and diastolic factors'expression such as ET-1 and NO. And closely related to the incidence of pre-eclampsia.

Key words: pre-eclampsia, oxidized low-density Lipoprotein, endothelin-1, nitric oxide