关键词: 高血压；勃起功能障碍；尿酸；内皮, 血管；一氧化氮；一氧化氮合酶；内皮微粒

Abstract: Abstract: Objective　To study the correlation between serum uric acid level with erectile dysfunction (ED) and vascular endothelial injury in male hypertensive patients. Methods　A total of 200 newly diagnosed hypertensive patients were included in the study. One hundred male hypertensive patients with ED were defined ED group (31 mild ED patients, 34 moderate ED patients and 35 severe ED patients) and 100 male hypertensive patients without ED who were matched in age were defined non-ED group according to international index of erectile function-5 (IIEF-5). Serum levels of uric acid were measured by uricase reagents. Serum nitric oxide (NO) and Endothelial nitric oxide synthase (eNOS) levels were tested by enzyme-linked immunosorbent assay. The level of plasma EMP was measured by flow cytometry. Results　Serum levels of uric acid and EMP were significantly increased in severe ED patients compared with those of moderate ED patients, mild ED patients and non-ED patients. These parameters were significantly increased in moderate ED patients compared with those of mild ED patients and non-ED patients. These parameters  were significantly increased in mild ED patients compared with those of non-ED patients. While serum levels of NO and eNOS were markedly decreased in severe ED patients compared with those of moderate ED patients, mild ED patients and non-ED patients. Serum levels of NO and eNOS were markedly decreased in moderate ED patients  compared with those of mild ED patients and non-ED patients (P＜0.05). Serum levels of NO and eNOS were markedly decreased in mild ED patients  compared with those of non-ED patients (P＜0.05). There was a negative  correlation between uric acid and NO as well as eNOS, and a positive correlation with EMP (P＜0.05) in all hypertensive patients. Uric acid was independently and positively associated with EMP in male hypertensive patients by stepwise multiple regression analysis. Logistic regresson analyses showed that serum uric acid level had independent relation with the occurrence of ED in hypertensive patients (P＜0.01). Area under receiver operating characteristic curve of uric acid to predict ED was 0.785 (95%CI: 0.717-0.852, P＜0.01). The optimal serum uric acid cut-point for predicting ED was 384.5 µmol/L, with a sensitivity of 90%, a specificity of 69%, a positive predictive value 74.8% and a negative predictive 87.3%. Conclusion　Hyperuricemia probably influences the occurrence and development of ED in male hypertension by promoting vascular endothelial injury.
Key words:hypertension; erectile dysfunction; uric acid; endothelium, vascular;nitric oxide;nitric oxide synthase;endothelial microparticle

Key words: hypertension, erectile dysfunction, uric acid, endothelium, vascular;nitric oxide;nitric oxide synthase;endothelial microparticle