天津医药

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2型糖尿病胫前黑斑患者T淋巴细胞亚群变化的探讨

敖小凤1,高志红2,邱明才3,何庆2   

  1. 1. 天津市塘沽区海洋石油总医院普内科
    2. 天津医科大学总医院内分泌科
    3. 天津医科大学总医院
  • 收稿日期:2010-03-11 修回日期:2010-05-15 出版日期:2010-12-15 发布日期:2010-12-15
  • 通讯作者: 敖小凤

The Research On T lymphocyte Function In Type 2 Diabetes Mellitus Patients With Black Patches On Pre-tibia

  1. 1.
    2. Tianjin Medical University General Hospital
  • Received:2010-03-11 Revised:2010-05-15 Published:2010-12-15 Online:2010-12-15
  • Contact: AO xiao-feng

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摘要：

目的:了解2型糖尿病(T2DM)胫前黑斑患者的T淋巴细胞亚群变化以及微血管病变情况。方法:根据有无胫前黑斑将64例糖尿病患者分为有斑组34例及无斑组30例,并与48例健康体检者对照(对照组),自动分析仪测定血糖、血脂代谢指标,流式细胞计数法测定外周血CD3+、CD4+、CD8+T细胞,并比较T2DM有斑组与无斑组微血管病发生率。结果:3组间TC、HDL-C、LDL-C差异无统计学意义(均P>0.05),无斑组及有斑组TG、FG、HbA1c明显高于对照组(P<0.05),无斑组及有斑组TG、FG、HbA1c差异无统计学意义(均P>0.05)。3组间CD3+差异无统计学意义,无斑组与对照组CD4+、CD4+/CD8+、CD8+差异无统计学意义(P>0.05),有斑组CD4+、CD4+/CD8+较对照组及无斑组升高,CD8+较对照组及无斑组降低(P<0.01或P<0.05)。有斑组微血管病变发生率高于无斑组(64.7%vs36.7%,P<0.05)。结论:胫前黑斑可能是T2DM患者免疫异常及微血管病变在皮肤的表现,皮肤黑斑及其他微血管并发症的发生可能与体内细胞免疫异常有关。

关键词: 2型糖尿病, 胫前黑斑, CD3+, CD4+, CD8+, CD4+/CD8+, T细胞

Abstract: 【abstract】Objective To investigate T lymphocyte function and prevalence of microangiopathy in Type 2 diabetes mellitus patients with black patches on pre-tibia. Methods Percentage of CD3+ to total lymphocytes was measured through flow cytometry, so were the percentages of CD4+ and CD8+ to T lymphocytes. Results (1) There was no significance between black-patch group and non-black-patch group in the percentage of CD3+ to total lymphocytes（P＞0.05）; The percentage of CD8+ to T lymphocytes in the black-patch group was significantly lower than that in the non-black-patch group （P＜0.01）; Both of the the percentage of CD4+ and the ratio of CD4+/CD8+ in the black-patch group were significantly higher than those in the non-black-patche group（P＜0.01）.(2) Incidence of chronic complications, especially microangiopathy, in the black-patche group was significantly higher than that in the non-black-patch group （P＜0.05）Conclusion Black patches on pre-tibia could be a dermatic sign of immune disorder and microangiopathy in type 2 diabetes mellitus. Black patches and other microangiopathy in type 2 diabetes mellitus could be related to disorder of cyto-immune function.

Key words: Type 2 diabetes mellitus, Black patches on pre-tibia, CD3+, CD4+, CD8+, CD4+/CD8+, T cell