天津医药

• 临床论丛 • 上一篇    下一篇

老年急性非ST段抬高型心肌梗死治疗药物的选择

陈哲明   

  1. 南京军区福州总医院
  • 收稿日期:2010-05-05 修回日期:2010-05-24 出版日期:2010-07-15 发布日期:2010-07-15
  • 通讯作者: 陈哲明

  • Received:2010-05-05 Revised:2010-05-24 Published:2010-07-15 Online:2010-07-15

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2014

摘要： 摘要 目的：观察替罗非班治疗急性非TS段抬高型心肌梗死(NTSEMI)的临床疗效。方法：将符合病例入选标准的110例老年NTSEMI患者随机分为2组，每组55例。2组均阿司匹林，入院后立即嚼服300mg，以后改为口服，300mg／d，3天减量至100mg／d；低分子肝素钙，5000U，皮下注射，2次／d；氯吡格雷，首剂顿服300mg，以后改为75 mg／次，3次／d；硝酸异山梨醇酯，20 m／次，口服，3次／d。观察组同时使用替罗非班，首次按每分钟5ug／kg剂量于3分钟静脉推注，再每分钟0.1ug／kg的维持量持续给药48小时。结果：治愈率观察组为80.00%，对照组为67.27%；总有效率观察组为92.73％，对照组为85.45%。2组相比差异有统计学意义（P＜0.05）。观察组治疗后各时段ST段恢复情况较对照组理想，2组相比差异有统计学意义（P＜0.05）。ST段恢复正常率观察组为87.27%，对照组为67.27%。2组相比差异有统计学意义（P＜0.05）。结论：在常规治疗的基础上使用替罗非班治疗急性非TS段抬高性心肌梗死临床疗效显著，可使病变的ST段恢复正常。

关键词: 急性非TS段抬高型心肌梗死, 替罗非班, 老年人

Abstract: Abstract Objective: To observe the tirofiban treatment of acute non-TS segment elevation myocardial infarction (NTSEMI) of clinical efficacy. Methods: Case selection criteria will meet the 110 elderly patients were randomly divided into 2 groups NTSEMI, 55 patients in each group. 2 groups were aspirin, immediately after admission Jiaofu 300mg, later changed to oral, 300mg/d,after 3 days reduction to 100mg/d; low molecular weight heparin, 5000U, subcutaneous injection, 2 times/d; chloride pyridine Gray, the first dose of Dayton suits 300mg, later changed to 75 mg / time, 3 times/d; isosorbide dinitrate, 20 m / second, oral, 3 times/d. Observation group using both tirofiban, the first per-minute 5ug/kg dose intravenous injection at 3 minutes, then the amount per minute 0.1ug/kg maintenance of sustained delivery of 48 hours. Results:The cure rate was 80.00% in the observation group and control group was 67.27%; total effective observation group was 92.73%,85.45% in control group. 2 groups was statistically significant difference compared(P<0.05). Observation group after treatment, the time ST segment in the ideal case than in the control group, compared with 2 groups was significantly(P<0.05). ST segment recovery rate were 87.27%,67.27% in control group. 2 groups was statistically significant difference compared(P<0.05).Conclusion:The use of conventional treatment on the basis of tirofiban treatment of acute non-TS segment elevation myocardial infarction significant ST segment lesions can return to normal.

Key words: acute non-segment elevation myocardial infarction TS, tirofiban, elderly