天津医药

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急性脑梗死患者血清中基质金属蛋白酶9和脂蛋白相关磷脂酶A2的动态改变

阳泽彬   

  1. 天津市公安医院
  • 收稿日期:2010-04-19 修回日期:2010-08-31 出版日期:2011-01-15 发布日期:2011-01-15
  • 通讯作者: 阳泽彬

The dynamic changes of matrix metalloproteinase-9 and lipoprotein associated-phospholipase A2 in sera of patients with acute brain infarction The dynamic changes of matrix metalloproteinase-9 and lipoprotein associated-phospholipase A2 in sera of patients with acute brain infarction

  • Received:2010-04-19 Revised:2010-08-31 Published:2011-01-15 Online:2011-01-15

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摘要： 摘要 目的：观察血清中基质金属蛋白酶-9和脂蛋白相关磷脂酶2在急性脑梗死中的临床应用价值。方法：对急性脑梗死患者146名，非脑梗死患者50名，健康体检者50名测定血清中此2项指标，进行比较分析。观察患者于入院当日，治疗后第5、10、15、20日的动态变化。结果：急性脑梗死组患者此2项指标明显高于其他2组。经治疗后随病情好转而下降。2项指标的升高程度与病情严重程度和梗死面积有一致关系。结论：2项指标的检测和动态观察有助于急性脑梗死的诊断、严重程度和梗死面积的判定，有望应用于临床。

关键词: 脑梗死, 基质金属蛋白酶9, 脂蛋白相关磷脂酶A2

Abstract: Abstract Objective：To observe the clinical usage of matrix metalloproteinase-9 and lipoprotein associated-phospholipaseA2 in acute brain infarction.Methods：146 acute brain infarction patients,50 non-infarction patients,and 50 heathy persons were observed. The 2 indexes in sera were examed and analysed. The dynamic changes on the day of administration and 5、10、15、20 days after treatment were compared.Conclusion：The 2 indexes and their dynamic changes can help the diagnosis and the evaluation of severity and infarction area.

Key words: brain infarctionmatrix metalloproteinase-9lipoprotein associated-phospholipaseA2brain infarction, matrix metalloproteinase-9, lipoprotein associated-phospholipaseA2