天津医药

• 论著 • 上一篇    下一篇

Caveolin-1与 Ki-67在宫颈癌中的表达及与HPV16/18的相关性

王颖   

  1. 天津大港医院
  • 收稿日期:2010-09-21 修回日期:2011-05-05 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 王颖

The expression of Caveolin-1 and Ki67 in cervical cancer and associated research with HPV16/18 infection

wangying   

  • Received:2010-09-21 Revised:2011-05-05 Published:2011-10-15 Online:2011-10-15
  • Contact: wangying

PDF (PC)

2151

摘要： 摘要]：目的: 研究Caveolin-1和ki-67在正常宫颈组织、宫颈上皮内瘤样变(CIN)以及宫颈癌中的表达情况及其与HPV感染的相关性，分析三者与宫颈癌相关临床病理指标的联系，探讨上述指标在宫颈癌发生、发展、浸润、转移中的作用及相互关系，为宫颈癌的诊断和治疗提供一种新的有效指标。方法: 采用免疫组化方法检测15例正常宫颈组织、35例CIN组织、50例宫颈癌组织中Caveolin-1和ki-67及HPV16/18的表达情况。结果: Caveolin-1和ki-67在宫颈癌组织中的阳性率与CIN、正常宫颈组织有显著性差异，且随着临床分期、病理分级的升高，阳性率差异有显著性，其表达率与淋巴结转移有关。HPV16/18在正常宫颈、CIN和宫颈癌组织中的阳性率逐渐升高，差异有显著性，但与临床分期、病理分级、年龄和淋巴结转移无关。结论: Caveolin-1与Ki-67在宫颈癌组织的异常表达与HPV感染有关，与宫颈癌的恶变程度有关。联合检测Caveolin-1、Ki-67和HPV可作为筛查宫颈癌和判断预后的有利指标。

关键词: 宫颈癌, Caveolin-1, Ki-67, 免疫组化, 发病机制

Abstract: Abstract] Objective :The goal of this study was to analyze relationship between the expression levels of Caveolin-1and Ki67 and HPV infection in normal cervical tissue，cervical intraepithelial neoplasia (CIN) and cervical carcinoma，and to analyze its relationship with clinicopathological parameters of cervical cancer-related links to explore the above-mentioned target happened in cervical cancer development，invasion and metastasis，for the diagnosis and treatment of cervical cancer to provide a new and effective target. .Methods : Using immunohistochemical method to detect the expression of Caveolin-1 and Ki67 and HPV in 15 cases of normal cervical tissue，35 cases of CIN tissue, 50 cases of cervical cancer . Results : significant difference for Caveolin-1and ki-67 was existed between normal cervical group and CIN group and cancer group.with increasing of clinical stages and tumor grades ,positive rates have signifucant difference,which were correlated with lymph node metastasis.The positive rate of HPV16/18 was significantly different between cervical cancer, CIN tissue and normal cervical tissue and was not associated with tumor grades ,clinical stages,age group and lymph node metastasis. Conclusion: expression of Caveolin-1 and ki-67 in cervical cancer tissue was correlated with HPV infection.Combined detection of Survivin and Ki-67 may be a new target of cancer diagnosis and treatment and a new way to assess the severity of cervical cancer.

Key words: cervical carcinoma, Caveolin-1 Ki-67, immunohistochemistry, clinicopathology