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系统性红斑狼疮并发肺动脉高压的临床分析

刘琦1,巩路2   

  1. 1. 天津市医科大学总医院
    2. 天津医科大学总医院感染科
  • 收稿日期:2010-12-24 修回日期:2011-04-24 出版日期:2011-11-15 发布日期:2011-11-15
  • 通讯作者: 刘琦

Clinical analysis of pulmonary arterial hypertension in systemic lupus erythematosus

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  • Received:2010-12-24 Revised:2011-04-24 Published:2011-11-15 Online:2011-11-15

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摘要： 【摘 要】 目的 筛查系统性红斑狼疮(SLE)患者肺动脉压，了解SLE并发肺动脉高压(PAH)的发病率，探讨与PAH相关性临床指标。方法 收集2009年8月至2010年1月入住天津总医院免疫科所有SLE患者66例，均行彩色多普勒超声心动图(UCG)检查，以PAH诊断标准分为PAH组和非PAH组，估算PAH发病率，并与临床资料进行组间相关分析。结果 ①SLE并发PAH的发病率为25.8%。②PAH的发生与雷诺现象、多浆膜腔积液和肺间质病变(ILD)呈正相关(r分别为0.318，0.416和0.267，P <0.05)，而与运动后呼吸困难、乏力、胸痛等无相关(P >0.05)。③PAH组较非PAH组的PLT、补体C3减低，GLO、IgG、CIC、RF升高，组间计数差异具有统计学意义（P <0.05）。结论 本组对SLE肺动脉压筛查显示PAH的发病率明显高于以往研究，提示SLE患者确诊初即应行肺动脉压筛查，以求尽早发现PAH和早期治疗。当SLE出现雷诺现象、多浆膜腔积液和ILD或伴有PLT、补体C3减低，GLO、IgG、CIC、RF升高时，PAH的发生率将增高。

关键词: 系统性红斑狼疮, 肺动脉高压, 彩色多普勒超声心动图

Abstract: 【Abstract】 Objective To investigate the morbidity of pulmonary arterial hy- pertension (PAH) in systemic lupus erythematosus (SLE) on the basis of pulmonary arterial pressure screening, and seek relational clinical index with PAH. Methods They have ordinary color Doppler echocardiography examination. According to the diagnostic criteria of PAH, divide them into PAH group and non-PAH group. Do statistical analysis between two groups, and contrast with previous literature. Results ①The morbidity of PAH in SLE is high to 25.8%.②The occurrence of PAH has positive relativity with Renault phenomenon, multiple serous effusions and interstitial lung disease(r is 0.318,.416 and 0.267 respectively, P <0.05). ③There’s statistic significance in decreasing of ALB, C3,PLT and increasing of GLO, IgG, CIC and RF in two groups(P <0.05). Conclusion SLE patients should have pulmonary arterial pressure general measure when initially diagnosed. The morbidity of PAH is obviously increased. When accompanied by Renault phenomenon, multiple serous effusions and interstitial lung disease etc, the morbidity of PAH in SLE may raise.

Key words: Systemic lupus erythematosus, Pulmonary arterial hypertension, Color Doppler echocardiography