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干扰素基因多态性与干扰素治疗慢性乙肝早期应答的关系

潘永平,樊晓慧   

  1. 南昌大学第四附属医院
  • 收稿日期:2010-12-16 修回日期:2011-04-19 出版日期:2011-11-15 发布日期:2011-11-15
  • 通讯作者: 潘永平

Study on the relationship between genetic polymorphisms of interferon and early response of interferon alpha

  • Received:2010-12-16 Revised:2011-04-19 Published:2011-11-15 Online:2011-11-15

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摘要： 目的 探讨干扰素启动子基因874位点的基因单核苷酸多态性与干扰素治疗慢性乙肝早期应答的关系。方法 选择我院住院及门诊慢性乙型病毒性肝炎（CHB）病人106名，应用多聚酶链式反应( PCR) 及限制片段长度多态性(RFLP) 分析宿主的IFN-r基因内含子1+874位点的基因单核苷酸多态性（SNP） ,患者给予干扰素（IFN-a） 治疗，比较SNP 与IFN-a 早期应答的关系。结果 早期无应答患者中AA基因型占77.3%，早期部分应答患者中AA基因型占42.4%，早期完全应答患者中AA基因型占43.1%。AA基因型患者干扰素治疗总体应答率不如其他两种基因型患者。结论 慢性乙肝患者对干扰素治疗的早期应答与IFN基因型有一定关联性，提示IFN-r基因型可能通过高表达或提高干扰素对宿主靶细胞的作用效率而取得更高疗效的。

关键词: 干扰素, 基因多态性, 慢性乙肝, 早期应答

Abstract: Objective To study the possible relationship between genetic polymorphisms of interferon and early response of interferon alpha Methods Clinical data from 145 patients in the original trial were analyzed. The SNP of INF-r gene intron at position1 +874 was determined by the restriction fragment length polymorphism analysis.all patients recieve interferon alpha treatment Results AA genetype account for 77.3% of early non-response patients, account for 42.4% of early part response patients, account for 43.1% of early complete response patients.AA genetype is associated with a lower early response rate compared with the other two genetypes. Conclusion There was association between IFN-r gene polymorphism and the early response of interferon alpha treatment in CHB patients. This study suggested the possibility that IFN-r gene polymorphism(intron 1 at position + 874) might be important in determining an individual’s efficacy of interferon alpha by higer expression or promting effect of host target cells

Key words: Interferon alpha, Gene polymorphism, Chronic Hepatitis B, early response