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Graves病患者肿瘤坏死因子α及甲状腺自身抗体水平研究

苏俊平1,苏胜偶2,3,张博2,4   

  1. 1. 河北省沧州市人民医院内分泌科
    2.
    3. 河北医科大学第二附属医院
    4. 河北省沧州市中心医院肿瘤外二科
  • 收稿日期:2010-11-12 修回日期:2011-02-25 出版日期:2011-11-15 发布日期:2011-11-15
  • 通讯作者: 苏俊平

The Relevance Study on TNF-α, thyroid autoantibody in GD patients with different iodine intake

  • Received:2010-11-12 Revised:2011-02-25 Published:2011-11-15 Online:2011-11-15

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摘要： 【摘要】目的 探讨不同碘摄入量Graves病（GD）患者体内细胞免疫30-crown-10体液免疫指标间的关系。方法 对临床诊断为GD患者,进行甲状腺细针细胞学检查,依据尿碘水平分为GDⅠ组与GDⅡ组，分别对其进行FT3、FT4、TSH、TGAb、TPOAb、TRAb、TNF-α联合测定。分析不同碘摄入量GD组各指标的差异及相关性。结果: GDⅠ组TGAb、TPOAb阳性率高于GDⅡ组(P<0.05)；GDⅠ组TRAb阳性率高于GDⅡ组(P＞0.05)；GDⅠ组TNF-α水平高于GDⅡ组（P<0.05）。相关分析显示，FT3与FT4、TRAb 、TPOAb呈直线正相关，TNF-α与TRAb、TPOAb呈直线正相关。结论 碘在GD的发病中起着重要作用，应限制GD患者的摄碘量。

关键词: Craves病, 尿碘, 甲状腺自身抗体, 肿瘤坏死因子

Abstract: Objective To investigate the relation of cellular immunological and humoral immunological indexs of the different iodine intake GD cases . Methods The clinical diagnosis GD cases were undertaked thyroid fine needle Cytology examination. Patients in GD group are divided into GD groupⅠand GD groupⅡ based on urinary iodine level. Detect the blood levels of FT3,FT4,TSH,TGAb,TPOAb,TRAb,TNF-α. Analyze the difference and dependablity of cellular immunological indexs and humoral immunological indexs of the different iodine intake GD cases .Results The positive rates of TGAb, TPOAb GDⅠgroup were higher than GDⅡgroup (P <0.05); The positive rates of TRAb GDⅠgroup were higher than GDⅡgroup (P ＞0.05); the TNF-α level in GDⅠgroup were higher than GD Ⅱ group, but the difference was not statistically significant (P <0.05). It was demonstrated by correlated analysis that FT3 was linear positive correlation with FT4、TRAb、TPOAb.，TNF-α was linear positive correlation with TRAb and TPOAb. Conclusion Iodine is important to development of Graves disease，it should be limited in patients with iodine excess.

Key words: 　Graves disease, urinary iodine, Thyroid auto-antibody, tumor necrosis factor