天津医药

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子痫前期的视网膜病变及其相关因素分析

王妍平1,牛秀敏2,3,陈叙1,3   

  1. 1. 天津市中心妇产科医院
    2. 天津医科大学总医院
    3.
  • 收稿日期:2010-09-07 修回日期:2010-12-16 出版日期:2011-04-15 发布日期:2011-04-15
  • 通讯作者: 王妍平

Retinopathy in preeclampsia and its associated factor

  • Received:2010-09-07 Revised:2010-12-16 Published:2011-04-15 Online:2011-04-15

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摘要： 摘要 目的: 回顾性分析足月分娩的子痫前期及妊娠期高血压患者的视网膜病变和各种临床实验室表现及胎儿体重的相关关系。方法: 分析参数为60例子痫前期及65例妊娠期高血压女性的视网膜病变，收缩压，舒张压，胎儿体重及各种生化指标，使用多元线性回归分析进行统计学处理。P＜0.05有统计学意义。结果: 子痫前期组视网膜病变的严重程度与胎儿体重负相关，与血清尿酸水平正相关。子痫前期组的其他变量包括血压（收缩期和舒张期）与视网膜病变没有明显相关性。在妊娠期高血压组，所分析的参数与视觉改变没有显著相关。结论: 子痫前期视网膜病变的严重程度与胎盘功能不全和宫内生长受限的程度直接相关，与收缩压没有明显相关性。

关键词: 子痫前期, 视网膜病变, 血压, 宫内生长受限, 尿酸

Abstract: Abstract Objective: Retrospectively study patients with preeclampsia and with gestational hypertension（GH） who delivered at term, the association of retinopathy with various clinical and laboratory manifestations and fetal birth weight was evaluated. Methods: Medical records of 60 patients with preeclampsia and 65 patients with GH who delivered at term were reviewed. Parameters analyzed were retinopathy, systolic and diastolic blood pressure (BP), fetal birth weight, and various biochemical parameters. Multivariable linear regression was used for statistical analysis. P＜0.05 was considered significant. Results: Severity of retinopathy was found to be inversely related to fetal birth weight (P＜0.05) and positively related to serum uric acid level (P＜0.05) in the preeclampsia group. All other variables in the preeclampsia group including systolic BP (mean, 166.4mmHg; P＞0.05) and diastolic BP (mean, 103.5mmHg; P＞0.05) were found to have no significant association with retinopathy. In the GH group, none of the parameters analyzed were significantly associated with ocular changes. Conclusions: The severity of retinopathy in preeclampsia is directly related to the level of placental insufficiency and intrauterine growth retardation. The severity of retinopathy might be independent of systemic BP.

Key words: Preeclampsia, Retinopathy, intrauterine growth retardation, Blood pressure, uric acid