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心房颤动合并慢性心力衰竭患者血浆利钠肽水平的变化研究

李霞   

  1. 天津医科大学一中心临床学院
  • 收稿日期:2010-09-09 修回日期:2010-12-10 出版日期:2011-05-15 发布日期:2011-05-15
  • 通讯作者: 李霞

Influence of atrial fibrillation on serum BNP levels of patients whit chronic heart failure

  • Received:2010-09-09 Revised:2010-12-10 Published:2011-05-15 Online:2011-05-15

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摘要： 目的 观察房颤（Atrial fibrillation,AF）对慢性心衰患者血清BNP浓度的影响。方法 选择2009年1月至2010年3月因心功能不全在我院心内科住院患者120例，根据12导联心电图分为房颤组（52）和窦性心律组(68)，按照美国纽约心脏病学会(New York Heart Association，NYHA)心功能的分级标准，又分为心功能Ⅱ级、心功能Ⅲ级、心功能Ⅳ级3个亚组。应用酶联免疫吸附法测定患者血清中BNP水平。结果 BNP水平随着心功能分级增加明显增高，在相同心功能级别房颤亚组血浆BNP水平较窦律组明显升高。结论 房颤是增加慢性心衰患者血BNP水平的独立因素,用BNP作为诊断心衰时应考虑房颤对其的影响。

关键词: 房颤, 慢性充血性心衰, BNP

Abstract: Abstract:Objective observe influence of atrial fibrillation on serum BNP levels of patients whit chronic heart failure. Method 120consecutive patients with signs and symptoms of heart failure who were referred to the heart failure at the between Jan 2009 and Mar 2010 were included on the study. atrial fibrillation group（52） and（68） were divided according to ECG，All subject were divided three groups according to New York Heart Association(NYHA). The plasma concentration of BNP was determined with ELISA assay.Results Plasma concentration of BNP in AF was significantly higher than that in si?nus rhythm group with the same heart fuction.Conclusion Atrial fibrillation is an independent determinant of increased BNP levels. This asso?ciation should be taken into account when BNP levels are used in the diagnosis of heart failure in pa?tients with atrial fibrillation.

Key words: Atrial fibrillation, Chronic congestie heart failure, BNP