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甲状腺乳头状癌组织学变型中ERα和VEGF的表达

金东岭1,席丰1,2,王蕾1,2,王广邑1,2   

  1. 1. 河北工程大学医学院
    2.
  • 收稿日期:2010-10-21 修回日期:2011-02-18 出版日期:2011-08-15 发布日期:2011-08-15
  • 通讯作者: 金东岭

Correlation between the expression of ERα and VEGF in different histopathological variants in patients of Papillar thyroid carcinoma

  • Received:2010-10-21 Revised:2011-02-18 Published:2011-08-15 Online:2011-08-15

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摘要： 目的：探讨雌激素受体α亚型（ERα）和血管内皮生长因子(VEGF)在人甲状腺乳头状癌各组织学变型中的表达及其相关性。方法：采用免疫组化SP法对59例甲状腺乳头状癌（PTC），56例甲状腺腺瘤和30例正常甲状腺组织中 ERα和VEGF的表达进行检测。结果：ＥＲα在甲状腺癌、甲状腺腺瘤和正常甲状腺中的阳性表达率分别为83.05%、58.93%和30.00%，差异有统计学意义 (P <0.01); VEGF在甲状腺癌和甲状腺腺瘤中的阳性表达率分别为64.41%和39.29%，而在正常甲状腺无表达，3组之间差异有统计学意义(P < 0.01)。淋巴结转移率较高的高细胞型和弥漫硬化型PTC中ERα和VEGF的阳性表达显著高于淋巴结转移率较低的乳头状微癌（P ＜0.05）。在PTC中ERα和VEGF的表达呈显著正相关（r =0.514，P = 0.033）。结论：ERα对甲状腺滤泡上皮的增生和分化以及甲状腺肿瘤的血管生成均具有促进作用，其过度表达与甲状腺癌的发生发展有密切关系。

关键词: 甲状腺肿瘤, 雌激素受体α亚型, 血管内皮生长因子, 免疫组织化学

Abstract: Objective：To investigate the correlation between the expression of estrogen receptor alpha(ERα) and vascular epithelial growth factor (VEGF) in different histopathological variants in patients of papillar thyroid carcinoma(PTC). Methods： Compare with and study the expression of ERα and VEGF which were examined by SP immunohistochemistry in 59 cases of PTC , 56 cases of thyroid adenoma, 30 cases of normal thyroid tissues. Results：The positive expression rate of ERα in cases with PTC, thyroid adenoma and normal thyroid tissue were 83.05%,58.93% and 30% respectively. There was significant difference between　　 PTC and adenoma or normal thyroid tissue(p<0.01).The positive expression rate of VEGF in cases with PTC, thyroid adenoma and normal thyroid tissue were 64.41%,39.29% and negative respectively. There was significant difference between　　 PTC and adenoma or normal thyroid tissue(p<0.01). The ERα and VEGF expression of PTC were related with the histological variant as well as lymph node metastasis（P＜0.05）.The ERα expression was positively correlated with the VEGF expression in PTC(r = 0.514，P = 0.033). Conclusion：The ERα may stimulate proliferation and promote differentiation of the thyroid epithelial cells. The increase of ERα expression may play a role in promote the angiogenesis and development of PTC.

Key words: thyroid tumor, ERα, VEGF, immunohistochemistry