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妊娠相关蛋白A在急性冠状动脉综合症诊断中的应用分析

曾昭伟1,李会强2,吴金丹3,4,谈志龙5,张连祥3,6,王学谦1   

  1. 1. 天津市天津医院
    2. 天津医科大学免疫学教研室
    3.
    4. 沃克（天津）生物公司
    5. 天津医院骨科研究所
    6. 天津市胸科医院
  • 收稿日期:2010-11-22 修回日期:2011-02-26 出版日期:2011-09-15 发布日期:2011-09-15
  • 通讯作者: 曾昭伟

Analysis of the Application of Pregnancy-associated Plasma Protein A to Diagnose the Acute Coronary Syndrome

  • Received:2010-11-22 Revised:2011-02-26 Published:2011-09-15 Online:2011-09-15
  • Contact: Zhao-Wei ZENG

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摘要： 摘要 目的：测定妊娠相关蛋白A（pregnancy-associated plasma protein A, PAPP-A）在正常人、稳定型心绞痛（SAP）以及冠状动脉综合症（ACS）患者中的浓度，分析其临床应用价值。方法：选取ACS 117例，并且跟踪ACS治疗后三周患者血清PAPP-A变化；稳定性心绞痛（SAP）患者68例；正常对照组84例。分别对上述标本行酶联免疫检测（ELISA）分析。结果：本研究检测了正常人、ACS以及SAP患者血清的PAPP-A浓度，发现PAPP-A浓度在ACS患者血清中含量最高，与SAP组和正常人组比较差别有统计学意义（q1=23.73, q2=31.32, 均P<0.01）。而SAP和正常人则无明显差异（q3=0.54, P>0.05）。在ACS治疗前后PAPP-A浓度变化有统计学意义(t=12.831，P<0.01)。结论：PAPP-A是一种有较大价值的ACS检测标志物，结合临床其他症状以及多种检测指示物，可以更好的用于临床上检测和预防ACS的存在，若进一步提高灵敏度，PAPP-A会有更好的临床应用。

关键词: 妊娠相关蛋白A, 急性冠状动脉综合症, 动脉粥样硬化, 酶联免疫检测, 标志物

Abstract: Abtract Objective: To detect the concentration of PAPP-A in the serum of the normal individuals, SAP and ACS, and analyze its clinical value. Methods: Picked 117 ACS samples, and followed all of them after therapy three weeks later. Also, picked 68 samples of SAP and 84 of nomal controls. Then, all of the above were detected with the ELISA method. Results: the concentration of PAPP-A in the samples of the normal individuals, ACS and SAP, the concentration in the ACS was highest, which had significant statistical meanings, (q1=23.73, q2=31.32, P<0.01). However, the findings between SAP and normal ones had non-statistical meaning, (q3=0.54, P>0.05). Also, we found that the PAPP-A congcentration had significant statistical meanings, (t=12.831, P<0.01). Conclusion: PAPP-A was of great value in detecting the ACS samples, complexed with the symptoms and other markers, it can have a much better application in predicting and preventing the ACS, if the sensitivity becomes higher, the clinical application of PAPP-A can be better.

Key words: pregnancy-associated plasma protein A, acute coronary syndrome, atherosclerosis, ELISA, marker