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支气管哮喘患者急性发作期血清中干细胞因子的测定及其临床意义

钱雪娇,蒋萍   

  1. 天津市第一中心医院
  • 收稿日期:2011-11-29 修回日期:2012-06-07 出版日期:2012-11-15 发布日期:2012-11-15
  • 通讯作者: 钱雪娇

Detection and Clinical Study of Stem Cell Factor in Serum of Acute Asthmatic Patients

  • Received:2011-11-29 Revised:2012-06-07 Published:2012-11-15 Online:2012-11-15

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摘要： 摘要 目的：探讨支气管哮喘患者急性发作期血清干细胞因子（SCF）的水平及意义，以及该细胞因子与血清中嗜酸粒细胞计数（EOS）、血清总免疫球蛋白E（T-IgE）、第1秒用力呼气流量（FEV1%）、呼出气一氧化氮（FeNO）之间的关系。方法：将65例支气管哮喘急性发作患者按病情严重程度分为轻、中、重度组，同时与同期37例健康人作对照，分别测定病例各组血清SCF、EOS,并随机测得病例各组血清T-IgE、FEV1%、FENO。结果：中、重度组治疗前血清SCF水平明显高于对照组及轻度组（P〈0.05），病例组治疗前血清SCF水平明显高于对照组（P〈0.05）。病例组血清SCF与EOS、T-IgE、FEV1%无明显相关性，与FeNO成正相关（r=0.447，P=0.004）。结论：血清SCF的水平可较准确反应气道炎症变化，可能与哮喘急性发作的严重程度有关。

关键词: 哮喘, 干细胞因子, 呼出气一氧化氮, 急性发作, 第一秒用力呼气流量

Abstract: Abstract Objective：To investigate the change and significance of stem cell factor(SCF)level in serum of patients with acute exacerbation of bronchial asthma，To explore the relationship of asthmatic patients with acute exacerbation SCF、T-IgE、FEV1 and FeNO. Methods：65 patients with acute exacerbation of bronchial asthma were divided into 3 groups with severity，37 normal subjects as control.The level of serum SCF 、EOS of 65 patients in each group were measured.The level of serum T-IgE, FEV1%and FeNO were tested quantitively.Results：Serum SCF levels in moderate and severe group were higher than that in control group and slight groups.(P<0.05). Serum SCF levels in asthmatic was higher than that in control group before treatment.(P<0.05). In asthmatic patients the level of SCF level did not correlate with EOS、T-IgE and FEV1% of predicted value,but it corrlated positively with FeNO（r=0.447，P=0.004）. Conclusion：The level of serum SCF maybe estimate accurately response airway inflammation changes,it maybe related to the severity of asthma attack.

Key words: asthma, stem cell fator, feno, acute exacerbation, forced expiratory volum at the first second