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冠心病患者颈动脉粥样硬化斑块与胆红素及尿酸水平的相关性研究

郑茹瑜1,周长钰2,孙春明1,芦雅萍1,3   

  1. 1. 天津医科大学第二医院
    2. 天津医科大学第二医院心脏科
    3.
  • 收稿日期:2011-06-23 修回日期:2011-10-21 出版日期:2012-02-15 发布日期:2012-02-15
  • 通讯作者: 郑茹瑜

Study on the Relationship of Serum Bilirubin and Uric Acid Level with Carotid Plaque in Patients of Coronary Heart Disease

  • Received:2011-06-23 Revised:2011-10-21 Published:2012-02-15 Online:2012-02-15
  • Contact: Ru-Yu ZHENG

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摘要： 目的：探讨冠心病患者颈动脉粥样硬化程度与胆红素及尿酸水平之间的关系。方法：选取184例冠心病患者，应用颈动脉超声技术检查颈动脉内中膜厚度（IMT），根据IMT值分为斑块组82例（IMT≥1.3 mm）和非斑块组102例（IMT<1.3 mm），记录患者的年龄、性别、高血压史、吸烟史等一般情况，血清总胆红素、直接胆红素、间接胆红素、尿酸等实验室指标，进行统计分析和处理。结果：冠心病患者颈动脉斑块组总胆红素、间接胆红素水平低于非斑块组，血尿酸水平高于非斑块组，差异有统计学意义（P<0.05），Pearson相关分析示总胆红素、间接胆红素水平与颈动脉斑块呈负相关，尿酸水平与颈动脉斑块呈正相关，Logistic逐步回归分析显示：间接胆红素、尿酸是颈动脉斑块形成的危险因素。结论：颈动脉粥样硬化的冠心病患者多伴有血清胆红素及尿酸的异常，干预二者的生成，可以早期预防冠心病患者急性心脑血管事件的发生。

关键词: 冠心病, 颈动脉粥样硬化斑块, 总胆红素, 间接胆红素, 尿酸

Abstract: Objective: To observe the relationship of carotid plaque with serum bilirubin and uric acid in patients of coronary heart disease(CHD). Methods: One hundred and eighty-four patients with CHD were enrolled in our study. All patients were examined for carotid intima-media thickness (IMT) by carotid artery ultrasound technology. According to the IMT, we divided the subjects into plaque group including eighty-two cases(IMT≥1.3mm) and non-plaque group including one hundred and two cases(IMT<1.3mm). The general conditions including age, sex, history of hypertension , smoking ,etal and laboratory parameters including the levels of total serum bilirubin, direct bilirubin, indirect bilirubin , uric acid, etal were recorded. All clinical data were statistically analyzed and processed. Results: The levels of total bilirubin and indirect bilirubin were lower in plaque group patients than those in non-plaque group patients, while the levels of uric acid were higher in plaque group patients than those in non-plaque group patients. All of these differences had statistical significance (P<0.05), Pearson correlation analysis indicated that the level of total bilirubin and indirect bilirubin negatively and the level of uric acid positively related with carotid plaque, the result of logistic step regression analysis showed that indirect bilirubin and uric acid were the independent risk factors of carotid plaque. Conclusion: Carotid atherosclerosis associated with abnormal serum bilirubin and uric acid in CHD patients. Interfering with the generation of bilirubin and uric acid may prevent cardiocerebrovascular incidents in CHD patients.

Key words: coronary heart disease, carotid plaque, total bilirubin, indirect bilirubin, uric acid