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分段血浆醛固酮／肾素活性比值对原发性醛固酮增多症的诊断效力

艾雪松1,林毅2,3,李黎明4   

  1. 1. 天津医科大学研究生院
    2. 天津医科大学总医院
    3.
    4. 天津医科大学总医院泌尿外科
  • 收稿日期:2011-07-19 修回日期:2011-10-11 出版日期:2012-05-15 发布日期:2012-05-15
  • 通讯作者: 艾雪松

The Diagnostic Power of Diffrent Stage of Aldosterone to Rein Ratio in Diagnostic Primary Aldosteronism

  • Received:2011-07-19 Revised:2011-10-11 Published:2012-05-15 Online:2012-05-15

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摘要： 摘要 目的 探讨血浆醛固酮/肾素比值对诊断原发性醛固酮增多症的准确性。 方法 计算我院经术后病理确诊的279例原发性醛固酮增多症（PA）患者及同期随机抽取的70例原发性高血压（PH）患者的血浆醛固酮/肾素活性比值(ARR)，以10为极差，分为11组，计算各个组段的PA和PH例数 及ARR值诊断PA的敏感度、特异度和Youden指数，并绘制ROC曲线。 结果 ARR在30～、40～、50～各组段内，诊断的敏感度、特异度及Youdon指数分别为83.2%、82.9%、0.661,77.8%、88.6%、0.664和74.2%、92.9%、0.671。 结论 ＡＲＲ在３０～６０之间时诊断原醛的敏感度、特异度及Ｙouden指数较高。

关键词: 原发性醛固酮增多症, 醛固酮/肾素比值, 敏感度, 特异度

Abstract: Abstract :Objective To evaluate the accuracy of aldosterone to rein ratio(ARR) in diagnosing primary aldosteronism(PA). Methods The aldosterone to rein ratio was determinned in 279 patients with primary aldosteronism and 70 patients with primary hypertension(PH),the patients were divided into 11 groups according to the range of 10. The numbers of PA and PH with diffent stage of ARR were determined,and the sensitivity,specificity,Youden index of ARR in diagnosing PA were caculated.The ROC curve was drawed.　Results The value of ARR in 30～、40～、50～, the sensitivity,specificity,Youden index of ARR in diagnosing PA were 83.2%、82.9%、0.661,77.8%、88.6%、0.664 and 74.2%、92.9%、0.671,respectively. Conclusion The sensitivity,specificity,Youden index of ARR in diagnosing PA are pretty high when ARR in 30～60.

Key words: primary aldosteronism, aldosterone to renin ratio, sensitivity, specificity