天津医药

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CRP，IL-6与冠状动脉狭窄程度的相关性分析

王卫定1,李广平2   

  1. 1. 天津医科大学第二医院心内科
    2. 天津医科大学第二医院心脏科
  • 收稿日期:2011-08-01 修回日期:2011-11-03 出版日期:2012-07-15 发布日期:2012-07-15
  • 通讯作者: 王卫定

Correlations with CRP, IL-6 and the severity of stenosis of coronary artery

,Guangping LI   

  • Received:2011-08-01 Revised:2011-11-03 Published:2012-07-15 Online:2012-07-15

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摘要： 摘要 目的：通过对行冠脉造影术患者的分析，研究C-反应蛋白（CRP）、白细胞介素-6（IL-6）与冠心病及冠脉狭窄程度的关系。方法：队列选取行冠状动脉造影术的患者共120例，分为对照组及冠心病组，冠心病组根据造影结果又分为单支、双支、三支病变组，检测CRP，IL-6水平，同时对冠脉造影结果进行评价及Gensini积分。结果：1. 冠心病组CRP及IL-6水平均高于对照组， CRP及IL-6是冠心病的独立危险因素。2. CRP，IL-6水平并未随着病变支数的增加而增加。3. CRP及IL-6与Gensini积分呈正相关，但均非其独立预测因子。结论： CRP和IL-6与冠心病有相关性，但CRP和IL-6并不能作为反映冠状动脉狭窄程度指标。

关键词: C-反应蛋白, 白介素-6, Gensini积分, 冠心病, 冠状动脉造影

Abstract: Abstract Objective: To study the Correlations with CRP, IL-6 and the severity of stenosis of coronary artery. Methods: 120 patients undergoing quantitative coronary angiography were involved in this study, and we measured the titer of CRP and IL-6. The severity scale of coronary artery stenosis was quantitatively assessed according to coronary angiography by Gensini score. The patients were categorized into control group and CAD group The CAD patients were classified to1, 2 and 3-vessel-lesion group according to the results of Angiography. Results: The CAD group had higher titers of CRP and IL-6 than the control group. In muiltvariate analysis, CRP and IL-6 were demonstrated to be independent risk factors. Neither CRP nor IL-6 were along with the number of lesion-vessels. In the correlation analyses, Gensini were significantly associated with IL-6, but neither CRP nor IL-6 were independent risk factors of Gensini score. Conclusion: CRP and IL-6 have correlation with CAD and are demonstrated to be significant predictors of CAD. But, nither CRP nor IL-6 are correlated with severity of CAD assessed by coronary angiography.

Key words: CRP, IL-6, Gensini score, Coronary heart disease, Coronary artery angiography