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Graves病和2型糖尿病患者血清视黄醇结合蛋白4和白细胞介素6水平变化

马启航1,樊继援2   

  1. 1. 天津医科大学总医院内分泌科
    2. 天津医科大学总医院
  • 收稿日期:2011-11-16 修回日期:2012-03-27 出版日期:2012-08-15 发布日期:2012-08-15
  • 通讯作者: 樊继援

The serum concentrations of RBP-4 and IL-6 in patients with Graves disease and Type 2 diabetes

Qi-Hang MA,   

  • Received:2011-11-16 Revised:2012-03-27 Published:2012-08-15 Online:2012-08-15

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摘要： 摘要 目的：测定Graves病和2型糖尿病患者血清中与胰岛素抵抗（IR）相关的因子视黄醇结合蛋白4（RBP-4）和白细胞介素6（IL-6）水平。方法：107例Graves病患者根据甲功水平分为Graves病初诊组54例、Graves病治疗组53例和2型糖尿病组53例，选择同期健康查体者50例作为对照组。抽取各组清晨空腹肘正中静脉血，测定血糖、胰岛素、游离三碘甲状腺原氨酸、游离甲状腺素、甲状腺球蛋白抗体、甲状腺过氧化物酶抗体、促甲状腺激素和促甲状腺受体抗体水平，酶联免疫吸附测定（ELISA）法检测血清RBP-4和IL-6的水平，并结合临床指标进行分析。结果：RBP-4的水平在Graves病初诊组、Graves病治疗组和2型糖尿病组高于对照组（均P＜0.001）。IL-6的水平在Graves病初诊组高于Graves病治疗组、2型糖尿病组和对照组（均P＜0.001）。结论：RBP-4和IL-6可能在Graves病IR的发病过程中有一定作用。

关键词: 格雷夫斯病, 视黄醇结合蛋白4, 白细胞介素6, 胰岛素抵抗, 甲状腺, 自身免疫疾病, 自身抗体, 脂肪细胞因子

Abstract: ? Abstract Objective: To investigate the serum concentrations of RBP-4 and IL-6 related to insulin resistance in patients with Graves disease and type 2 diabetes.Methods: One hundred and seven patients with Graves diease were divided into initial diagnosis group(n=54) and treatment group (n=53) . Type 2 diabetes group(n=53).Fifty healthy subjects were selected for the control. The levels of glucose，insulin，free triiodothyronine ，free thyroxine，thyrotropin，antithyroglobulin antibody ，anti-thyroperoxidase antibody and anti-thyrotropin receptor were detected using fasting blood. The serum levels of RBP-4 and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA).Result:The serum levels of RBP-4 in initial diagnosis group, treatment group and type 2 diabetes group were higher than control group(P＜0.001、P＜0.001、P＜0.001). The serum levels of IL-6 in initial diagnosis group were higher than the treatment group ,type 2 diabetes group and control group (P＜0.001、P＜0.001、P＜0.001). Conclusion:Insulin resistance in Graves disease patient may relate to high serum level of RBP-4 or IL-6.

Key words: graves disease, retinol-binding protein 4, interleukin-6, insulin resistance, thyroid gland, autoimmune diseases, autoantibodies, 脂肪细胞因子