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代谢综合征对急性心肌梗死后左心室功能的影响

于恒池   

  1. 首都医科大学附属北京友谊医院内分泌科
  • 收稿日期:2011-06-07 修回日期:2012-01-01 出版日期:2012-08-15 发布日期:2012-08-15
  • 通讯作者: 于恒池

Effect of metabolic syndrome on left ventricular function after acute myocardial infarction

  • Received:2011-06-07 Revised:2012-01-01 Published:2012-08-15 Online:2012-08-15

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摘要： 目的 观察代谢综合征对急性心肌梗死后左心室射血分数（LVEF）的影响。方法　入选首次急性心肌梗死患者共161例，根据是否合并代谢综合征，分为合并代谢综合征组(n=86)与无代谢综合征组(n=75)，所有患者分别于发病后72 h内、发病后30 d行超声心动图检查测量左室舒张末期容积（LVEDV）和LVEF。结果 急性心肌梗死患者中代谢综合征的患病率为56.4%，代谢综合征组在入院时及30d随访时的左室舒张末期容积均显著大于无代谢综合征组（入院时：139.5ml±41.3ml比 124.4ml±36.9ml，P=0.016；30 d随访时：154.1ml±40.8ml比 139.1ml±36.3ml，P=0.016），但两组的LVEF水平在入院时及30d随访时均无显著差异。（入院时：49.4%±7.2% 比 50.4%±8.3%，P=0.377；30 d随访时：52.5%±6.8%比54.3%±8.3%，P=0.119）。结论　代谢综合征在急性心肌梗死患者中具有较高的患病率，但对于心肌梗死患者近期左室射血分数无显著影响。

关键词: 急性心肌梗死, 代谢综合征, 左心室射血分数

Abstract: Objective To investigate the effect of metabolic syndrome on left ventricular function after AMI onset. Methods We prospectively studied the relationship between metabolic syndrome and left ventricular function in 161 patients with AMI. Patients were grouped to metabolic syndrome group(n=86）and non metabolic syndrome group(n=75）. left ventricular end diastolic volume （LVEDV） and LVEF were measured at admission and at 30 days after AMI onset. Results 56.4％of the 161 AMI patients were complicated with MS. Compared with non MS group, LVEDV of MS were increased (for admission: 139.5ml±41.3ml vs.124.4ml±36.9ml，P=0.016; for 30 days: 154.1ml±40.8ml vs.139.1ml±36.3ml，P=0.016)，and There was no difference in LVEF between the 2 groups（for admission: 49.4%±7.2% vs.50.4%±8.3%，P=0.377; for 30 days: 52.5%±6.8% vs.54.3% ±8.3%，P=0.119）. Conclusions There were high prevalence of MS in patients with AMI, and there were not significant effect of MS on left ventricular function after AMI onset.

Key words: myocardial infarction, metabolic syndrome, left ventricular ejection fraction