天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (8): 840-844.doi: 10.11958/j.issn.0253-9896.2015.08.003

• 专题研究·心血管疾病（主编：李广平） • 上一篇    下一篇

中性粒细胞/淋巴细胞比值对急性心肌梗死患者预后的价值

郭星梅，王东昕，韩聪聪，李姮，崔丽，徐延敏   

  1. 天津医科大学第二医院心内科
  • 收稿日期:2015-07-20 修回日期:2015-07-31 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 徐延敏 E-mail:303075417@qq.com
  • 作者简介:郭星梅（1987），女，硕士在读，主要从事冠心病基础与临床研究

Prognostic value of Neutrophil-to-Lymphocyte ratio in patients with ST-segment elevation myocardial infarction

GUO Xingmei，WANG Dongxin，HAN Congcong，LI Heng，CUI Li，XU Yanmin   

  1. Department of Cardiology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Received:2015-07-20 Revised:2015-07-31 Published:2015-08-15 Online:2015-08-15
  • Contact: XU Yanmin E-mail:303075417@qq.com

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摘要： 目的 探讨中性粒细胞/淋巴细胞比值（NLR）对急性ST 段抬高型心肌梗死（STIMI）并行经皮冠状动脉介入（PCI）治疗患者发生不良事件的预测价值。方法 选取我院326 例STIMI 患者，根据NLR 分为T1 组（≤3.46）、T2 组（3.47~6.75）和T3 组（>6.75）。收集患者一般临床资料、实验室指标、冠脉造影结果、术后TIMI 分级及左室射血分数（LVEF），记录患者住院期间心力衰竭、支架内血栓再形成、室速/室颤、房颤、房室传导阻滞、心源性休克等不良事件的发生情况以及随访6 个月主要心血管不良（MACE）事件如非致命性心梗、死亡、心衰再入院、缺血性卒中的发生情况。结果 T3 组住院期间心衰、房颤、室速/室颤及心源性休克的发生率明显高于其余两组（P<0.05），冠脉多支病变发生率明显高于T1 组（54.1% vs 37.0%），且术后梗死相关动脉TIMI 3 级的患者比例明显低于T1 组（83.5% vs 94.4%），住院期间LVEF 明显低于T1 组（0.48±0.10 vs 0.52±0.10）。随访6 个月，3 组非致命性心梗、死亡、缺血性卒中的发生率差异无统计学意义，而T3 组的因心力衰竭再入院率明显高于T1 组（P<0.05）。结论 NLR 可能会作为急性心肌梗死患者心衰发生的预测指标。

关键词: 心肌梗死, 淋巴细胞, 预后, 心力衰竭, 急性心肌梗死, 中性粒细胞/淋巴细胞比值

Abstract: Objective To investigate the clinical prognostic value of neutrophils to lymphocyte ratio（NLR）in patients with ST-segment elevation myocardial infarction（STIMI）who underwent percutaneous coronary intervention（PCI）. Methods A total of 326 patients with acute ST segment elevation myocardial infarction were enrolled. According to the neutro⁃ phils to lymphocyte ratio, patients were divided into group T1（≤ 3.46）, group T2（3.47-6.75）and group T3（> 6.75）. Basic clinical data，laboratory indexes，coronary angiography results, TIMI grading and left ventricular ejection fraction（LVEF） were collected in all groups. Incidence of adverse events in hospital such as acute heart failure, thrombosis, ventricular tachy⁃ cardia and ventricular fibrillation, atrial fibrillation, atrioventricular block and cardiogenic shock, were recorded. Major ad⁃ verse cardiac events（MACE）, death of all causes, non-fatal MI, ischemic stroke and readmission due to heart failure at the 6-month follow-up were also noted. Results The incidence of heart failure, atrial fibrillation, ventricular tachycardia/ven⁃ tricular fibrillation and cardiogenic shock was higher in group T3 than those in the other two groups（P < 0.05）.The inci⁃ dence of multivessel coronary artery disease was significantly higher in group T3 than that in group T1 (54.1% vs 37.0%, P < 0.05). The percentage of TIMI grade 3 in post-operative infracted artery was significantly lower than that in group T1 (83.5% vs 94.4%). Left ventricular ejection fraction was significantly lower in group T3 than that of group T1 during hospital⁃ ization (0.48±0.10 vs 0.52±0.10). There was no significant difference in the incidences of death, non-fatal MI, ischemic stroke at 6 month follow up. But the rate of readmission due to heart failure was significantly higher in group T3 than that in the group T1（P < 0.05）. Conclusion Neutrophils to lymphocyte ratio may be a useful marker to predict the prognosis of pa⁃ tients with heart failure due to acute myocardial infarction.

Key words: myocardial infarction, lymphocytes, prognosis, heart failure, acute myocardial infarction, neutrophil-tolymphocyte ratio