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心型脂肪酸结合蛋白对急性肺栓塞患者近期预后的预测价值

何磊   

  1. 河北省 邢台市人民医院
  • 收稿日期:2011-10-21 修回日期:2012-03-02 出版日期:2012-09-15 发布日期:2012-09-15
  • 通讯作者: 何磊

The predictive value of H-FABP for the acute pulmonary embolism patients in recent prognosis

  • Received:2011-10-21 Revised:2012-03-02 Published:2012-09-15 Online:2012-09-15

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摘要： 目的：评价心型脂肪酸结合蛋白（H-FABP）对急性肺栓塞患者近期预后的预测价值。 方法：自2009年8月至2011年7月连续入选邢台市人民医院87例急性肺栓塞患者，入院后测定H-FABP水平，根据血H-FABP测定值分为2组：阳性组：H-FABP≥10ng/mL（n=21），阴性组：H-FABP<10ng/mL（n=66）。比较H-FABP阳性组与H-FABP阴性组间晕厥、休克、死亡等不良事件发生率的差异。同时比较有无临床不良事件发生的患者血H-FABP水平差异。 结果： H-FABP阳性组中发生晕厥、休克、右心功能不全，曾行溶栓治疗、机械通气机率明显增加，与H-FABP阴性组比较，有统计学差异（P<0.05）；30天死亡共2例，均发生在H-FABP阳性组。出现临床不良事件组血H-FABP水平（15.23 ng/mL±2.92 ng/mL）明显高于无不良事件组（5.49 ng/mL±3.36 ng/mL），存在统计学差异（P<0.01）。 结论：H-FABP升高是急性肺栓塞患者近期死亡的危险因素，提示预后不良，有助于对急性肺栓塞患者进行危险分层。

关键词: 肺栓塞, 脂肪酸结合蛋白质类, 预后

Abstract: Objective： To evaluate the predictive value of heart -type fatty acid-binding protein (H-FABP) for the acute pulmonary embolism patients in recent prognosis . Methods: From August 2009 to July 2011, 87 patients with acute pulmonary embolism were enrolled in people's hospital of Xingtai . After be in hospital the H-FABP level of these patients were determined. According to the blood H-FABP determination values ,87 cases were divided into two groups. Positive group: H-FABP ≥10 ng/mL (n = 21), negative group: H-FABP < 10 ng/mL (n = 66). And we have compared the different rates of adverse events between the two groups in syncope, shock and death .At the same time we have respectively compared the different blood H-FABP levels between the two groups when these clinical adverse events happen or not. Result: In the positive group it has higher incidence in Syncope, shock ,right heart dysfunction, fibrinolytic therapy,and mechanical ventilation. These all have statistically significant (P < 0.05). Total 2 deaths had occurred in H-FABP positive group during the 30 days. H-FABP level in the group with clinical adverse events（15.23 ng/mL±2.92 ng/mL）is significantly higher than the group without adverse events（5.49 ng/mL±3.36 ng/mL）.The result has statistically significant differences (P < 0.01). Conclusion: H-FABP increase is the risk factor in the recent death of acute pulmonary embolism patients and indicates poor prognosis . It provides effective risk stratification for the acute pulmonary embolism patients.

Key words: Acute pulmonary embolism, Heart-type fatty acid-binding protein, Recent prognosis