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血清尿酸与其他危险因素交互作用对高血压的影响

王媛媛   

  1. 天津医科大学第二医院心内科
  • 收稿日期:2012-04-24 修回日期:2012-09-24 出版日期:2013-02-15 发布日期:2013-02-15
  • 通讯作者: 王媛媛

Interaction between serum uric acid and other risk factors in relation to hypertension

WANG Yuan yuan   

  1. The Second Hospital of Tianjin Medical University, Tianjin 300211, China
  • Received:2012-04-24 Revised:2012-09-24 Published:2013-02-15 Online:2013-02-15
  • Contact: WANG Yuan yuan

摘要:

目的 探讨血清尿酸与高血压的关系,研究血清尿酸与年龄、肥胖、血糖和血脂交互作用对该关系的影响。方法 以天津大港油田3 318例常住居民为研究对象,将研究对象按血清尿酸水平四分位间距分成4组,调查其吸烟、饮酒、家族史等情况,测量血压、体质量,检测血糖、血脂和尿酸等指标,对相关数据进行统计分析。结果 4组的年龄、血压、体质指数(BMI)、空腹血糖、总胆固醇、三酰甘油和低密度脂蛋白胆固醇(LDL-C)基本随尿酸水平增加而呈增高的趋势,而高密度脂蛋白胆固醇(HDL-C)随尿酸升高而降低;校正相关因素后,研究对象患高血压的OR 值随血清尿酸水平的升高而升高。分层分析结果 显示血清尿酸水平与LDL-C的交互作用对高血压患病的影响在 LDL-C高水平组最显著(P=0.01)。结论 血清尿酸与高血压相关联,血清尿酸与LDL-C交互作用可能影响这种关联性。

关键词: 尿酸, 高血压, 血糖, 胆固醇, 胆固醇, HDL, 胆固醇, LDL

Abstract:

[Abstract] Objective  To investigate the relationship between serum uric acid and hypertension, and to evaluate the effects of interaction between serum uric acid and other risk factors on hypertension. Methods  The total of 3 318 permanent residents in Tianjin Dagang oilfield were included in this study. All subjects were divided into four groups according to the serum uric acid quartiles. The related factors such as smoking, drinking and family history were investigated. Levels of blood pressure, body mass index (BMI), fasting plasma glucose (FPG), lipid and uric acid were detected and analyzed. Results  The levels of age, blood pressure, BMI, FPG, serum total cholesterol, triacylglycerol and low density lipoprotein cholesterol (LDL-C) were increased with the increase in the level of serum uric acid, but the level of high density lipoprotein cholesterol (HDL-C) was decreased with the increase in the level of uric acid. After adjustment for relevant factors, OR values of hypertension increased with the elevated uric acid levels. The effect of interaction between levels of uric acid and LDL-C was significantly higher in subjects with high levels of LDL-C (P=0.01). Conclusion  The elevated serum uric acid level was associated with hypertension, which was affected by the interaction between serum uric acid and LDL-C.

Key words: uric acid hypertension blood glucosecholesterol cholesterol, HDL cholesterol, LDLtriglyceridestransactional analysis, LDL