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脂联素与慢性阻塞性肺病相关性研究

张德刚   

  1. 兰州大学第二临床医院
  • 收稿日期:2013-04-15 修回日期:2013-06-25 出版日期:2014-01-15 发布日期:2014-01-15
  • 通讯作者: 张德刚

Correlation study of Adiponectin and Chronic Obstructive Pulmonary Disease

  • Received:2013-04-15 Revised:2013-06-25 Published:2014-01-15 Online:2014-01-15

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摘要： 目的 研究脂联素与慢性阻塞性肺病 （COPD） 患者肺功能、 年龄、 性别的相关性。方法 选择COPD急性加重期 （急性加重组） 和稳定期 （稳定组） 患者各60例， 另择60例健康者为对照组， 3组男、 女均各30例， 采用ELISA
法检测血清脂联素， 使用肺功能测试仪测量并计算FEV1/FVC、 FEV1%预计值和RV/TLC。结果 急性加重组总体、男性和女性脂联素水平均高于稳定组和对照组， 且稳定组高于对照组 （均P＜0.05）； 3组女性脂联素水平均高于男性
（均P＜0.05）。急性加重组和稳定组FEV1%、 FEV1/FVC预计值均低于对照组， 且急性加重组和稳定组的RV/TLC均
高于对照组 （均P＜0.05）。急性加重组与稳定组血清脂联素水平与FEV1%预计值、 FEV1/FVC均呈负相关， 与RV/TLC呈正相关 （均P＜0.01）。除正常男性血清脂联素与年龄呈正相关 （r=0.943， P＜0.01） 外， 其余组二者均无相关性 （P＞0.05）。结论 COPD患者血清脂联素水平明显升高， 推测脂联素起促炎作用并与气道阻力有关； 血清脂联素存在性别差异， 并可能与年龄有关。

关键词: 血清脂联素, 慢性阻塞性肺病, 肺功能, 性别, 年龄

Abstract: Abstract] Objective To study the relationship between adiponectin and pati ents of chronic obstructive pulmonary disease (COPD) with pulmonary function,age and gender.Method 120 COPD patients with normal body mass index (BMI<24kg/m2 ) were selected,including 60 patients with acute exacerbations of COPDand 60 patients with stable COPD.And 60 healthy people were included as controls.The number of Male were equal to female in each group.This experiment was to detect the plasma adiponectin of these groups. Pulmonary function results were collected and FEV1/FVC, FEV1%predicted, RV/TLC were calculated in all subjects.Result The concentrations of plasma adiponectin of patients in acute exacerbations and stable of COPD were significantly higher than those of controls. (P<0.01). Lung function including FEV1/FVC and FEV1%predicted of patients in acute exacerbations and stable of COPD were significantly higher than those of controls. (P<0.01).But RV/TLC in acute exacerbations and stable of COPD were significantly lower than those of controls. The plasma adiponectin concentrations of female was higher than the male,and it had a significant difference (P<0.05).The concentrations of plasma adiponectin were negatively correlated with FEV1/FVC（r=-0.839，P<0.01）and FEV1%predicted(r=-0.633,P<0.01),but positively correlated with RV/TLC(r=0.864, P<0.01).Plasma adiponectin levels of male in controls were significant positively related (r=0.943,P<0.01)with age while female in controls,male and female in stable and acute exacerbations of COPD were no correlation with age (P>0.05).Conclusion Plasma adiponectin concentrations of patients in COPD were significantly elevated which suggested that adiponectin in COPD play an important part in pro-inflammatory and might be closely related with airway resistance.Plasma adiponectin concentrations might be exist in gender differences.Adiponectin concentration can be related with age.

Key words: Plasma adiponectin, Chronic Obstructive Pulmonary Disease, pulmonary function, gender, age