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磷酸肌酸钠对老年高血压并心力衰竭患者血浆CT-1、NT-proBNP的影响

殷国田1,杨萌1,解娜2,李波1,黄艳梅1,魏旭明1,任明芬3   

  1. 1. 新乡医学院第三附属医院
    2. 新乡医学院第三附属医院心内科
    3. 新乡医学院第二附属医院
  • 收稿日期:2013-07-23 修回日期:2013-08-21 出版日期:2014-01-15 发布日期:2014-01-15
  • 通讯作者: 任明芬

Changes of plasma cardiotrophin-1 and N terminal probrain natriuretic in elderly hypertensive patients with heart failure by phosphocreatine therapy

  • Received:2013-07-23 Revised:2013-08-21 Published:2014-01-15 Online:2014-01-15

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摘要： 目的 探讨磷酸肌酸钠对老年高血压并心力衰竭 （心衰） 患者血浆心肌营养素-1 （CT-1）、 N末端B型利钠肽原 （NT-proBNP） 水平的影响。方法 选择年龄≥65岁的高血压并心衰患者76例， 分层随机法分为治疗组和对照组各38例， 对照组常规抗心衰治疗， 治疗组常规抗心衰治疗加用磷酸肌酸钠， 2周后评定2组血浆CT-1、 NT-proB?NP的变化及心衰症状情况。血浆CT-1水平采用双抗体夹心酶联免疫吸附法 （ELISA） 测定， NT-proBNP水平采用锐普荧光干式定量分析仪检测。结果 治疗后2组血浆CT-1、 NT-proBNP水平均较治疗前降低 （P＜0.01）， 治疗组血浆CT-1、 NT-proBNP水平较对照组下降更明显 （P＜0.05）。治疗组总有效率89.47%， 高于对照组的71.05% （P＜0.05）。治疗组1周心衰症状改善21例， 2周13例， 对照组1周9例， 2周18例。结论 常规治疗加用磷酸肌酸钠可降低老年高血压并心衰患者血浆CT-1和NT-proBNP水平， 在更短的时间内改善患者心力衰竭症状。

关键词: 磷酸肌酸钠, 老年, 高血压, 心力衰竭, 心肌营养素-1, N端脑钠肽

Abstract: Abstract objective To observe the changes of plasma cardiotrophin-1(CT-1) and N terminal probrain natriuretic (NT-pro BNP) in elderly hypertensive patients with heart failure by phosphocreatine therapy．Methods 76 hypertensive patients with heart failure , aged 65 or over were randomly divided into treatment group and control group (n=38, each)．The control group received routine anti-heart failure treatment. The treatment group received conventional therapy plus creatine phosphate sodium for 2 weeks. Plasma CT-1 and NT-pro BNP were determined in all subjects. Plasma CT-1 level was measured by a double antibody sandwich enzyme-linked immunosorbent assay (ELISA). NT-pro BNP concentration was tested by Pu Rui fluorescent dry quantitative analyzer. Results Plasma CT-1 and NT-pro BNP of two groups were lower after treatment (P＜0.01). The level of Plasma CT-1 and NT-pro BNP in treatment group was significantly decreased than that in control group (P＜0.01, P＜0.05). There was statistic difference in total effective rate ( 89.47% in treatment group /71.05% in control group , P < 0.05). The time needed in improving heart failure symptoms was shorter in treatment group (P < 0.05). Conclusions Conventional therapy plus creatine phosphate sodium decrease plasma CT-1 and NT-pro BNP levels in elderly hypertensive patients with heart failure and this therapy works faster in improving symptoms of heart failure.

Key words: Phosphocreatine, elderly, hypertension, heart failure, cardiotrophin-1, N terminal probrain natriuretic