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冠心病患者网膜素-1与高敏C反应蛋白的相关性分析

刘海亮1,张慧霞1,张浩2,张瑞波1,杨丽娟2,刘淑婧1   

  1. 1. 黄河三门峡医院心血管内科
    2. 黄河三门峡医院
  • 收稿日期:2013-08-09 修回日期:2013-09-22 出版日期:2014-02-15 发布日期:2014-02-15
  • 通讯作者: 刘海亮

Study of the relationship between Serum Omentin-1 and Serum high sensitive C-reactive protein in Coronary heart disease

  • Received:2013-08-09 Revised:2013-09-22 Published:2014-02-15 Online:2014-02-15
  • Contact: Hai Liang LIH

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摘要： 目的 观察冠心病患者网膜素-1(Omentin-1)、高敏C反应蛋白(hs-CRP)水平，分析网膜素-1、高敏C反应蛋白与冠心病的相关性。方法 采集68例冠心病患者分为不稳定型心绞痛(UAP)组36例，稳定型心绞痛(SAP)组32例，另选择30例冠状动脉造影结果正常者为对照组。采用酶联免疫吸附法(ELISA)测定血清 Omentin-1水平，采用增强免疫透射比浊法测定血清hs-CRP水平。结果 血清 Omentin-1 在UAP和SAP组中低于对照组，差异有统计学意义(P<0.05)，血清 hs-CRP在UAP组和SAP组中高于对照组，差异有统计学意义(P<0.05)，血清 hs-CRP在UAP组与SAP组之间差异有统计学意义(P＜0.05)，而血清 Omentin-1在UAP组与SAP组之间差异无统计学意义(P>0.05)；血清 Omentin-1在单支、双支、三支病变组中均低于对照组(F＝22.02，P<0.05)，血清 hs-CRP在单支、双支、三支病变组中均高于对照组(F＝19.78，P<0.05)，但在单支、双支与三支病变组之间差异均无统计学意义(P>0.05)。经Pearson’s相关分析，血清Omentin-1与hs-CRP的浓度呈显著负相关（r＝-0.543，P＜0.01)。结论Omentin-1、hs-CRP，与冠心病存在一定的相关性，但并不能反映冠状动脉狭窄程度及范围。

关键词: 网膜素-1, 高敏C反应蛋白, 冠心病, 心绞痛, 动脉粥样硬化

Abstract: Objective To evaluate the correlation of Omentin-1 , the high sensitivity C-reactive protein(hsCRP) and coronary heart disease (CHD) by test the serum level of them. Methods Sixtyeight patients with CHD were divided into the unstable angina pectoris (UAP) group (n =36) and the stable angina pectoris (SAP) group (n=32), 30 normal subjects without CHD diagnosed by coronary arteriography(CAG) served as the control group. The serum level of Omentin-1 is measured by enzyme linked immune sorbent assay (ELISA) and the serum level of hsCRP is measured by turbidmetric immunoassay. Results The serum level of Omentin-1 were lower in UAP and SAP group than control group (P<0.05). The serum level of hsCRP were higher in UAP and SAP group than control group (P<0.05).The mean level of hsCRP in UAP group was differently significantly, compared with that in SAP (P>0.05) .While the Omentin-1 is the opposite. The mean level of Omentin-1 in single, double and three vessel lesion group were lower than that in control group (F＝22.02，P<0.05) .The mean level of hsCRP in single, double and three vessel lesion group were higher than that in control group (F＝19.78，P<0.05), but the serum levels of Omentin-1or hsCRP among single, double and three were not significant different (P>0.05). The serum level of Omentin-1and hsCRP were significantly negative correlation in Spearman correlation coefficients (r＝-0.543,P＜0.01). Conclusions Omentin-1 and hsCRP may correlate with CHD. However, may not reflect the severity of artery stenosis.

Key words: Omentin-1, High sensitive C-reactive protein, Coronary heart disease, Angina pectoris, Arteriosclerosis