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ING4和CDX2在结直肠癌中的表达及其与预后的关系

刘俊远1,黄桂林1,李志刚2,丛竹军3,孙旭凌3,祝磊3   

  1. 1. 新疆石河子大学医学院
    2. 新疆石河子大学第一附属医院普外二科
    3. 新疆石河子大学医学院第一附属医院普外二科
  • 收稿日期:2013-07-31 修回日期:2013-09-24 出版日期:2014-02-15 发布日期:2014-02-15
  • 通讯作者: 黄桂林

Expression and prognosis significance of ING4 and CDX2 in colorectal cancer

  • Received:2013-07-31 Revised:2013-09-24 Published:2014-02-15 Online:2014-02-15

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摘要： 【摘要】目的 探讨生长抑制因子4（ING4）和尾型同源盒转录因子2（CDX2）在结直肠癌中的表达及与预后的关系。方法 应用免疫组织化学法检测99例结直肠癌组织和30例癌旁正常组织中ING4、CDX2的表达，结合术后随访资料，分析其表达与临床病理特征及预后的关系。结果 ING4、CDX2在癌组织中表达的阳性率分别是67.7%和72.7%，显著低于癌旁正常组织（p＜0.05）。且二者的表达与组织分化程度、浸润深度、淋巴结转移及肿瘤分期密切相关（p＜0.05）。ING4阴性者5年生存率(35.5%)明显低于ING4阳性者(77.9%); CDX2阴性者5年生存率(48.1%)明显低于CDX2阳性者(70.8%)。结直肠癌组织中ING4、CDX2表达呈正相关。结论 ING4和CDX2的表达与结直肠癌发生、发展及患者生存率密切相关，联合检测两者的表达对于结直肠癌的临床诊断及预后判断有重要意义。

关键词: 结直肠肿瘤, 生长抑制因子4, 尾型同源盒转录因子2, 预后

Abstract: Abstract Objective:To investigate expression and prognostic significance of ING4 and CDX2 in colorectal cancer.Methods:The expressions of ING4 and CDX2 proteins were detected by immunohistochemistry in colorectal cancer tissues from 99 cases of colorectal cancer and normal colorectal tissues from 30 corresponding para-cancerous normal tissues. The data for clinic outcomes were collected. The correlations between the expressions of ING4、CDX2 and clinicopathological parameters were also analyzed. Results: The positive expression rates of ING4 and CDX2 were 67.7% and72.7% in the colorectal cancer tissues,the positive rate were significantly lower in colorectal cancer than that innormal tissue group (p＜0.05)．Both of ING4 and CDX2 expressions in colorectal cancer tissues were correlated with histological grade,infiltration depth,lymph node metastasis and TNM staging(p＜0.05). The 5-year survival rate in the ING4 negative group(35.5%) was lower compared with the ING4 positive group (77.9%) ; The 5-year survival rate in the CDX2 negative group(48.1%) was lower compared with the CDX2 positive group (70.8%) . ING4 was positively correlated with CDX2. Conclusion: The expressions of ING4 and CDX2 are strongly associated with the carcinogenesis, development and prognosis of the cancer，which indicates that ING4 and CDX2 might be taken as prognostic markers for the colorectal cancer．

Key words: Colorectal cancer, ING4, CDX2, Prognosis