天津医药

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代谢综合征与三阴性乳腺癌关系的研究进展

田垚1,王毅2,朱科云3,汪百川4,曹旭晨5   

  1. 1. 天津医科大学
    2. 天津市东丽医院
    3. 慈溪市人民医院
    4. 新疆医科大学
    5. 天津肿瘤医院
  • 收稿日期:2014-05-27 修回日期:2014-06-28 出版日期:2014-09-15 发布日期:2014-09-15
  • 通讯作者: 田垚

Research Progress on the Relationship between Metabolic Syndrome and

Yao TIAN1,WANG Yi 2,ZHU Keyun 2,WANG Baichuan 2,CAO Xuchen 3   

  1. 1. Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical UniversityTianjin 300060, China
    2. Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical University,Tianjin 300060, China
    3. Corresponding Author E-mail：cxc@medmail.com.cn
  • Received:2014-05-27 Revised:2014-06-28 Published:2014-09-15 Online:2014-09-15
  • Contact: Yao TIAN

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摘要： 【摘要】代谢综合征（MS）、乳腺癌是女性常见疾病，三阴性乳腺癌（TNBCs）是近年来备受关注的乳腺癌的一个类型。MS的重要组分向心性肥胖、高血糖、高甘油三酯和低高密度脂蛋白（HDL-C）增加了TNBCs的患病风险。MS的常见生物标记物胰岛素、脂联素和瘦素等在乳腺癌特别是TNBCs的发生发展中起到重要作用。胰岛素样生长因子-IImRNA结合蛋白3(IMP3，是一种癌胚蛋白)可能是TNBCs浸润性癌新的生物标记物。本文对MS与TNBCs关系的研究进展进行综述。

关键词: 代谢综合征X, 乳腺肿瘤, 胰岛素, 瘦素, 脂联素, 综述, 三阴性乳腺癌

Abstract: 【Abstract】Metabolic syndrome (MS) and breast cancer are common diseases of women. Triple negative breast cancer (TNBCs) is one type of breast cancer which is of much attention in recent years. Important components of MS include central obesity, high blood sugar, high triglycerides and low high-density lipoprotein (HDL-C) increased the incidence risk of TNBCs. Common biomarkers of MS which are insulin, adiponectin and leptin play an important role in the occurrence and development of breast cancer especially TNBCs. Insulin-like growth factor-IImRNA binding protein 3 (IMP3, an oncofetal protein) may be TNBCs’ new invasive cancer biomarkers. In this paper, the progress of research on the relationship between MS and TNBCs will be reviewed.

Key words: metabolic syndrome X, breast neoplasms, insulin, leptin, adiponectin, review, triple-negative breast cancers