天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (5): 529-532.doi: 10.11958/j.issn.0253-9896.2015.05.022

• 应用研究 • 上一篇    下一篇

慢性肾衰竭终末期患者下颌骨骨密度的研究

刘建山， 李孝英， 王英， 王珊， 彭诚△   

  1. 天津医科大学第二医院 （邮编 300201）
  • 收稿日期:2015-01-10 修回日期:2015-02-15 出版日期:2015-05-15 发布日期:2015-05-25
  • 通讯作者: 彭诚 E-mail:peng_cheng2013@163.com E-mail:peng_cheng2013@163.com
  • 作者简介:刘建山 （1989）， 男， 硕士在读， 主要从事口腔颌面部错颌畸形的矫治
  • 基金资助:
    天津市卫生局科技基金项目 （2014KZ095）

Research on mandibular bone mineral density in patients with end-stage renal disease

LIU Jianshan， LI Xiaoying，WANG Ying， WANG Shan， PENG Cheng△   

  1. The Second Hospital of Tianjin Medical University, Tianjin 300201, China
  • Received:2015-01-10 Revised:2015-02-15 Published:2015-05-15 Online:2015-05-25
  • Contact: PENG Cheng,E-mail:peng_cheng2013@163.com E-mail:peng_cheng2013@163.com
  • Supported by:
    Tianjin health bureau of science and technology fund

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摘要： 摘要： 目的 研究用曲面断层下颌指数（PMI）评价慢性终末期肾衰竭患者下颌骨及全身骨密度（BMD）的有效性。方法 选择行腹膜透析的患者 30 例为研究组， 健康成人 31 例为对照组， 拍摄 2 组的全颌曲面断层片， 测量颏孔上缘 PMI（sPMI）和颏孔下缘 PMI（iPMI）， 双能 X 线仪测量腰椎 BMD， 比较 2 组的上述指标， 分析 sPMI、 iPMI 与腰椎 BMD 的相关性。结果 研究组的 sPMI（0.262 2±0.026 7 vs 0.284 2±0.025 4， t=3.301）、 iPMI（0.314 1±0.028 3 vs 0.334 1±0.027 5， t=2.808）、 腰椎 BMD（0.832 3±0.101 0 vs 0.906 9±0.113 6， t=2.709）均较对照组低（P < 0.01）； sPMI、 iPMI 与腰椎 BMD 呈正相关（r 分别为 0.439、 0.389， P < 0.05)。对照组中女性的腰椎 BMD 低于男性（0.849 7±0.114 7 vs 0.968 0±0.076 3， t=3.357）， 研究组中女性的腰椎 BMD 低于男性 （0.775 4±0.068 4 vs 0.882 1±0.099 9， t=3.365）， 差异均有统计学意义； 2 组中不同性别间 sPMI、 iPMI 的差异均无统计学意义。结论 慢性终末期肾衰竭患者下颌骨 BMD 较正常人低， PMI 是一种简单、 有效的测量下颌骨 BMD 的方法， 并可以在一定程度上反映慢性终末期肾衰竭患者全身 BMD 的变化情况。

关键词: 慢性肾衰竭, 骨密度, PMI, 全颌曲面断层片, 下颌骨

Abstract: Abstract：Objective To investigate the effectiveness of panoramic mandibular index (PMI) in detecting the bone min⁃ eral density (BMD) of mandibular bone and whole-body bone in patients with chronic end-stage renal failure. Methods A total of thirty patients with peritoneal dialysis treatment were used as experimental group and 31 healthy adults were used as control group. The panoramic jaw tomography was taken for the measurement of superior PMI (sPMI) and inferior PMI (iPMI) in two groups. The dual-energy X-ray absorptiometry (DXA) was used to detect BMD of lumbar spine bone. Data were com⁃ pared between two groups. The correlation of sPMI, iPMI and BMD of lumbar spine bone was analyzed. Results All indica⁃ tors including sPMI(0.262 2±0.026 7 vs 0.284 2±0.025 4, t=3.301) , iPMI (0.314 1±0.028 3 vs 0.334 1±0.027 5, t=2.808) and BMD of lumbar spine bone (0.832 3±0.101 0 vs 0.906 9±0.113 6，t=2.709) were significantly lower in experimental group than those in control group (P < 0.01). There was a positive correlation between sPMI and iPMI with BMD of lumbar spine bone (r=0.439 and 0.389, P < 0.05). The BMD of lumbar spine bone was significantly lower in female patients than that of male patients in control group (0.849 7±0.114 7 vs 0.968 0±0.076 3， t=3.357). The BMD of lumbar spine bone was also sig⁃ nificantly lower in female patients than that of male patients in experimental group (0.775 4±0.068 4 vs 0.882 1±0.099 9， t= 3.365). There were no significant differences in values of sPMI and iPMI between male and female patients of two groups. Conclusion The BMD of mandibular bone is lower in patients with chronic end-stage renal failure than that of the normal people. PMI index is a simple and effective method to detect the BMD of mandibular bone, which can reflect the BMD of whole body bone in patients with chronic end-stage renal disease.

Key words: chronic renal failure, bone mineral density, panoramic mandibular index, panoramic tomogram, mandibular