天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (7): 781-784.doi: 10.11958/j.issn.0253-9896.2015.07.022

• 应用研究 • 上一篇    下一篇

产妇血清和新生儿脐带血中总 IgE 与特应性皮炎的关系及过敏原检测

曾三武，孟令贺，王得玲，邹映雪，汤乃军，陈叙，魏文国，金京姬，齐放，索丹凤   

  1. 1 天津市第一中心医院皮肤科
    2 天津市儿童医院；
    3 天津医科大学；
    4 天津市中心妇产科医院
  • 收稿日期:2014-10-28 修回日期:2015-02-16 出版日期:2015-07-15 发布日期:2015-07-15
  • 通讯作者: 曾三武 1△ E-mail:sanwuzeng@sohu.com
  • 基金资助:
    产妇血清和新生儿脐带血中的IgE、IL-4和IL-18的水平与特应性皮炎关系的研究

The relationship between total IgE and atopic dermatitis in maternal serum and neonatal umbilical cord blood and allergen testing

ZENG Sanwu, MENG Linghe, WANG Deling, ZOU Yingxue, TANG Naijun, CHEN Xu, WEI Wenguo,JIN Jingji, QI Fang, SUO Danfeng   

  1. 1 Department of Dermatology, Tianjin First Centre Hospital; 
    2 Tianjin Children Hospital;
    3 Tianjin Medical University; 4 Tianjin Central Hospital of Gynecology Obstetrics

  • Received:2014-10-28 Revised:2015-02-16 Published:2015-07-15 Online:2015-07-15
  • Contact: ZENG Sanwu1△ E-mail:sanwuzeng@sohu.com

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摘要： 摘要： 目的 探讨产妇血清和新生儿脐带血中总IgE与儿童特应性皮炎（AD）的相关性及过敏原检测的临床意义。方法 选取2009—2011年建立的出生队列中诊断为AD的儿童35例（AD组），随机选取未患AD的35例儿童作为对照（对照组），ELISA法分别检测儿童出生前产妇血清和新生儿脐带血中的总IgE水平，定量免疫印迹法检测血清特异性IgE水平。 结果 AD组中母亲血清和新生儿脐带血总IgE阳性率高于对照组(χ2分别为16.568和14.933，均P < 0.01)。AD组中母亲血清过敏原中尘螨，屋尘，豚草花粉，嵩类花粉，杨、柳及榆树花粉，霉菌，虾，海洋鱼类特异性IgE阳性率高于对照组（均P < 0.05）；AD患儿脐带血过敏原中嵩类花粉，霉菌IgE阳性率高于对照（均P < 0.05）。结论 母亲血清总IgE升高可能会对婴儿后期罹患AD起预测作用；母亲的过敏状态与婴儿的过敏状态无明显一致性。

关键词: 皮炎, 特应性,  胎血,  免疫球蛋白 E,  特应性皮炎,  脐带血,  产妇血清,  总 IgE,  特异性 IgE,  过敏原检测

Abstract: Abstract： Objective To explore the correlation of maternal serum and newborn cord blood total IgE and childhood atopic dermatitis (AD), as well as its clinical significance of allergen testing. Methods Selected 35 cases which were diagnosed as AD(AD group), and randomly selected 35 cases of the baby who were not diagnosed as AD (control group) from a birth cohort established in 2009—2011.Detected maternal serum and newborn cord blood total IgE level by the ELISA method. Used quantitate immunoblotting method to detect serum specific IgE antibody level. Results The serum total IgE level of the mothers and cord blood in the AD group are significantly higher than the control group (χ2=16.568 and 14.933，P < 0.01). Compared to the control group, there was statistical significance of dust mites, house dust, ragweed pollen, song kind of pollen, poplar, surname and elm pollen, mould, shrimp, marine fish of mother serum allergen in AD group（P < 0.05）; there was statistical significance of song kind of pollen, mould of newborn cord blood in AD group（P < 0.05）. Conclusion Advanced mother serum total IgE may play a predictive effect on infants suffering` from AD.There is no obvious consistency in allergic state between mothers and infants.

Key words: dermatitis atopic, fetal blood, immunoglobulin E, atopic dermatitis, cord blood, maternal serum, total IgE,
specific IgE, allergen test