天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (9): 1079-1081.doi: 10.11958/j.issn.0253-9896.2015.09.034

• 综述 • 上一篇    下一篇

线粒体DNA损伤与视网膜色素上皮细胞关系的研究进展

俞永珍， 邹秀兰， 邹玉平△   

  1. 1广州军区广州总医院眼科 （邮编510010）； 2广州医科大学附属第三医院眼科
  • 收稿日期:2014-06-24 修回日期:2015-04-10 出版日期:2015-09-15 发布日期:2015-09-15
  • 通讯作者: △通讯作者 E-mail： gzzouyuping@sina.com E-mail:xlzou2003@yahoo.com.cn
  • 作者简介:俞永珍 （1989）， 女， 研究生， 硕士， 主用从事眼底病研究
  • 基金资助:
    广东省科技计划项目 （2011B031800202， 2012B031800409）

The relationship between mitochondrial DNA damage and retinal pigment epithelium cells

YU Yongzhen, ZOU Xiulan, ZOU Yuping△   

  1. Department of Ophthalmology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China;
  • Received:2014-06-24 Revised:2015-04-10 Published:2015-09-15 Online:2015-09-15
  • Contact: △Corresponding Author E-mail： gzzouyuping@sina.com E-mail:xlzou2003@yahoo.com.cn

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摘要：  线粒体 DNA （mtDNA） 是线粒体内具有遗传效应的双股闭环 DNA 分子， 对细胞及其功能具有重要作用。视网膜色素上皮 （RPE） 细胞活动亦由大量线粒体参与。因 RPE 细胞代谢活跃， 当发生氧化应激时可引起线粒体及 mtDNA 损伤； 当线粒体及 mtDNA 损伤无法及时修复而使损伤积累， 可引起 RPE 及线粒体功能障碍， 并诱发启动细胞凋亡， 进而引发某些眼病， 如年龄相关性黄斑变性等。现就 mtDNA 与 RPE 细胞的功能关系、 mtDNA 损伤修复及检测方法作一综述。

关键词: DNA, 线粒体, DNA 损伤, 视网膜色素类, 上皮细胞, 活性氧\ 综述

Abstract: Abstract： Mitochondrial DNA (mtDNA) is a genetic effect DNA molecule of double closed loop, and is crucial for cells and their functions. Mitochondria take an active part in physiological activities of retinal pigment epithelium (RPE) cells. The oxidative stress is usually occurred in RPE for its active metabolism, which can lead to mitochondria and mtDNA dam⁃ age. Once mitochondria and mtDNA lesions have not been repaired timely, the lesions can be accumulated, which can cause dysfunctions and damaged-structures of RPE and mitochondria, and can motivate the progression of cell apoptosis. In the end it can result in some ocular related diseases such as aged-related macular degeneration (AMD). This study reviewed the functional relationship between mtDNA and RPE, and repair and detection methods of mtDNA damage.

Key words: DNA, mitochondrial, DNA damage, retinal pigments, epithelial cells, reactive oxygen species, review