天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (11): 1305-1307.

• 内分泌专题 • 上一篇    下一篇

血清甲状腺过氧化物酶抗体对 Graves 病合并桥本 甲状腺炎的诊断意义

任丽萍 1， 卢泽芬 2， 何庆 3△， 于佳 4   

  1. 1 天津大学医院 （邮编 300072）； 2 沧州市人民医院； 3 天津医科大学总医院； 4 天津市海河医院
  • 收稿日期:2016-08-05 修回日期:2016-10-29 出版日期:2016-11-15 发布日期:2016-11-15
  • 通讯作者: △通讯作者 E-mail：hech69@hotmail.com E-mail:Hech69@hotmail.com
  • 作者简介:任丽萍 （1973）， 女， 主治医师， 硕士， 主要从事自身免疫性甲状腺疾病的研究
  • 基金资助:
    国家自然科学基金资助项目 （81570144， 81270144）

The diagnositic significance of serum thyroid peroxidase antibody in patients with Graves disease and Hashimoto’ s thyroiditis

REN Liping1, LU Zefen2, HE Qing3△, YU Jia4   

  1. 1 Tianjin University Hospital, Tianjin 300072, China; 2 Cangzhou People’ s Hospital; 3 Tianjin Medical University General Hospital; 4 Tianjin Haihe Hospital
  • Received:2016-08-05 Revised:2016-10-29 Published:2016-11-15 Online:2016-11-15
  • Contact: △Corresponding Author E-mail: hech69@hotmail.com E-mail:Hech69@hotmail.com

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摘要： 目的 探讨血清甲状腺过氧化物酶抗体（TPOAb）对 Graves 病（GD）、 Graves 病合并桥本甲状腺炎（GH）诊 断的临床意义。方法 选取 2008 年 1 月—2014 年 12 月天津医科大学总医院外科临床确诊为 GD、 并经手术治疗的 患者 58 例， 术后依据甲状腺病理结果分为 GD 组 39 例和 GH 组 19 例。比较 2 组血清 TPOAb 水平及甲状腺内淋巴 细胞浸润程度。结果 GD 组术前血清 TPOAb 水平明显低于 GH 组［60.0（15.0， 317.0）IU/mL vs. 800.0（231.6， 1 000.0） IU/mL， P＜0.01］； 甲状腺淋巴细胞浸润程度明显低于 GH 组（Z=4.334， P＜0.01）。结论 GH 患者相比于单 纯 GD 患者血清 TPOAb 水平更高、 甲状腺内淋巴细胞浸润程度更重。

关键词: 碘化物过氧化物酶, 抗体, 格雷夫斯病, 桥本病, 淋巴细胞

Abstract: Objective To study the clinical significance of the serum thyroid peroxidase antibody (TPOAb) for the diagnosis of Graves disease (GD) and Graves with combined Hashimoto thyroiditis (GH). Methods Fifty-eight in-patients who were diagnosed as GD and underwent thyroidectomy in the Department of General Surgery at Tianjin Medical University General Hospital between January 2008 and December 2014 were enrolled in this study. Patients were divided into GD group (n=39) and GH group (n=19) according to the postoperative pathological results of the thyroid gland. The serum TPOAb titer and the degree of thyroid lymphocytic infiltration were compared between two groups. Results The preoperative serum TPOAb titer was obviously lower in GD group than that in GH group [60.0 (15.0， 317.0) IU/mL vs. 800.0 (231.6, 1000.0) IU/mL, P＜0.01]. The degree of thyroid lymphocytic infiltration was obviously lower in GD group than that of GH group (Z=4.334, P＜0.01). Conclusion The serum TPOAb titer and the degree of thyroid lymphocytic infiltration are higher in GH patients than those in patients with GD alone.

Key words: iodide peroxidase, antibodies, Graves disease, Hashimoto disease, lymphocytes