天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (4): 444-448.doi: 10.11958/20203082

• 综述 • 上一篇    

氯胺酮滥用致认知障碍与海马改变的研究进展

彭金芝1，李晓东2，王乾兴1△   

  1. 1遵义医科大学细胞生物学教研室（563000）；2广州华佑戒毒医院有限公司
  • 收稿日期:2020-11-10 修回日期:2021-01-12 出版日期:2021-04-15 发布日期:2021-04-16
  • 通讯作者: 王乾兴 E-mail:317002641@qq.com
  • 作者简介:彭金芝（1984），女，硕士在读，主要从事成瘾医学研究。E-mail：jinzhi_peng@foxmail.com
  • 基金资助:
    国家科技部重点研发计划（2016YFC0800907）

Research progress of cognitive dysfunction and hippocampal changes induced by ketamine abuse#br#

PENG Jin-zhi1, LI Xiao-dong2, WANG Qian-xing1△   

  1. 1 Department of Cell Biology, Zunyi Medical University, Zunyi 563000, China; 
    2 Guangzhou Huayou Detoxification Hospital Co .Ltd
  • Received:2020-11-10 Revised:2021-01-12 Published:2021-04-15 Online:2021-04-16
  • Contact: WANG Qian-xing E-mail:317002641@qq.com

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摘要： 氯胺酮是一种广泛应用于临床麻醉的解离麻醉剂，因具有致幻作用在全球范围内出现不同程度的滥用。氯胺酮滥用可引起多方面的认知障碍，造成较大的家庭和社会负担。鉴于海马在认知中起着重要作用，本文就氯胺酮滥用所致的认知障碍及其与海马结构和功能改变的关系进行综述，为深入认识氯胺酮滥用所致的认知障碍及其治疗提供新的思路和策略。

关键词: 氯胺酮, 物质相关性障碍, 认知障碍, 海马, 神经元, 细胞凋亡, 细胞死亡

Abstract: As a dissociative anesthetic, ketamine is widely used in clinical surgery anesthesia. Because of its hallucinogenic effect, ketamine has been abused in different degrees aroud the world. Ketamine abuse increases the burden of family and social expenditure because it can cause many aspects of cognitive dysfunction. In view of the crucial role of hippocampus in cognitive activities, this paper reviews the relationship between cognitive dysfunction caused by ketamine abuse with the structural and functional changes of hippocampus. The aim is to provide new ideas and strategies for the prevention and treatment of cognitive dysfunction caused by ketamine abuse.

Key words: ketamine, substance-related disorders, cognition disorders, hippocampus, neurons, apoptosis, cell death

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