天津医药

天津医药 ›› 2022, Vol. 50 ›› Issue (1): 35-40.doi: 10.11958/20211115

• 胆道闭锁专题 • 上一篇    下一篇

GATA6抑制肝星状细胞活化在胆道闭锁肝纤维化中的研究进展

杨仁杰1，2，3，张聪1，2，詹江华2△   

  1. 1天津医科大学研究生院（邮编300070）；2天津市儿童医院普外科；3新疆伊犁州友谊医院小儿外科
  • 收稿日期:2021-05-12 修回日期:2021-11-18 出版日期:2022-01-15 发布日期:2022-01-19
  • 通讯作者: 詹江华 E-mail:zhanjianghuatj@163.com
  • 基金资助:
    新疆维吾尔自治区自然科学基金面上项目（2019D01A12）

Research progress of GATA6 inhibiting hepatic stellate cell activation in hepatic fibrosis of biliary atresia

YANG Renjie1, 2, 3, ZHANG Cong1, 2, ZHAN Jianghua2△   

  1. 1 Graduate School of Tianjin Medical University, Tianjin 300070, China; 2 Department of General Surgery, Tianjin Children’s Hospital; 3 Department of Pediatric Surgery, Xinjiang Yili Friendship Hospital
  • Received:2021-05-12 Revised:2021-11-18 Published:2022-01-15 Online:2022-01-19
  • Contact: zhanjianghua E-mail:zhanjianghuatj@163.com

PDF (PC)

2761

摘要：

摘要：胆道闭锁（BA）以肝内外胆管进行性炎性阻塞和肝纤维化为特征，是引起婴幼儿梗阻性黄疸的常见原因之一。肝门空肠吻合术（Kasai术）是BA患儿的首选治疗手段。及时有效解除胆管炎性阻塞、遏制肝纤维化是延长或实现BA患儿自体肝生存的关键。GATA结合蛋白6（GATA6）具有调节转录活性的功能，可通过调控细胞增殖分化、协同上调铁调素的表达以及参与丝裂原活化蛋白激酶（MAPKs）依赖的信号通路等途径抑制肝星状细胞（HSCs）的活化，促进HSCs衰老，减轻肝纤维化，在BA肝损伤后肝修复过程中发挥一定的作用。该文就GATA6的功能特点、作用途径及其与BA肝纤维化之间的关系进行综述。

关键词: 胆道闭锁, 肝硬化, GATA6转录因子, 肝星状细胞

Abstract:

Abstract: Biliary atresia (BA) is characterized by progressive inflammatory obstruction of intrahepatic and extrahepatic bile ducts and hepatic fibrosis, which is one of the common causes of obstructive jaundice in infants. Kasai surgery is the first choice for children with BA. Timely and effectively relieving inflammatory obstruction of bile duct and curbing liver fibrosis are the key to prolong or realize autologous liver survival in children with BA. GATA binding protein 6 (GATA6) has the function of regulating transcriptional activity. Studies have shown that it can inhibit the activation of hepatic stellate cells (HSCs) by regulating cell proliferation and differentiation, up-regulating the expression of ferritin and participating in mitogen-activated protein kinase-dependent signal pathway, promote HSCs senescence, reduce liver fibrosis, and play a certain role in the process of liver repair after BA liver injury. This article intends to review the relationship between GATA6 and BA liver fibrosis from the aspects of functional characteristics and pathways of action.

Key words: biliary atresia, liver cirrhosis, GATA6 transcription factor, hepatic stellate cells

中图分类号: