七氟烷对海马神经元凋亡相关信号通路影响的研究进展

doi:10.11958/20212285

天津医药 ›› 2022, Vol. 50 ›› Issue (8): 892-896.doi: 10.11958/20212285

• 综述 • 上一篇

七氟烷对海马神经元凋亡相关信号通路影响的研究进展

谢云帆(), 刘咪, 田毅()

中南大学湘雅医学院附属海口医院麻醉科（邮编570208）

收稿日期:2021-11-01 修回日期:2022-04-01 出版日期:2022-08-15 发布日期:2022-08-12
通讯作者: 田毅 E-mail:xieyunfan1vip@163.com;tianyi1975@126.com
作者简介:谢云帆（1997）,男,硕士在读,主要从事术后认知方面研究。E-mail： xieyunfan1vip@163.com
基金资助:
国家自然科学基金资助项目(81660195);海南省自然科学基金资助项目(821RC724)

Research progress on effects of sevoflurane on apoptosis related signal pathways of hippocampal neurons

XIE Yunfan(), LIU Mi, TIAN Yi()

Department of Anesthesiology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou 570208, China

Received:2021-11-01 Revised:2022-04-01 Published:2022-08-15 Online:2022-08-12
Contact: TIAN Yi E-mail:xieyunfan1vip@163.com;tianyi1975@126.com

谢云帆, 刘咪, 田毅. 七氟烷对海马神经元凋亡相关信号通路影响的研究进展[J]. 天津医药, 2022, 50(8): 892-896.

XIE Yunfan, LIU Mi, TIAN Yi. Research progress on effects of sevoflurane on apoptosis related signal pathways of hippocampal neurons[J]. Tianjin Medical Journal, 2022, 50(8): 892-896.

摘要/Abstract

摘要：

七氟烷是一种广泛使用的吸入性麻醉药,其对于认知功能的影响日益受到关注。该药可造成神经毒性,导致神经元损伤、凋亡和认知功能障碍。神经元凋亡途径包括内源性凋亡途径、外源性凋亡途径以及内质网途径,而凋亡相关信号通路在其中发挥重要作用,如磷脂酰肌醇-3-激酶/蛋白激酶B（PI3K/Akt）、核因子κB（NF-κB）和丝裂原活化蛋白激酶（MAPK）等信号通路。对七氟烷引起海马神经细胞凋亡中的可能相关信号通路进行综述。

关键词: 七氟烷, 细胞凋亡, 海马, 信号通路, 综述

Abstract:

Sevoflurane is a widely used inhalation anesthetic, and there is growing concern about its effects on cognitive function. Sevoflurane can cause neurotoxicity, resulting in neuronal damage, apoptosis and cognitive dysfunction. Neuronal apoptotic pathways include the endogenous apoptotic pathway, the exogenous apoptotic pathway and the endoplasmic reticulum pathway. Apoptosis-related signaling pathways, such as phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt), nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK), play an important role in these pathways. This paper reviews the recent literature in this field and provides a review of the possible signaling pathways involved in sevoflurane-induced apoptosis in hippocampal neuronal cells.

Key words: Sevoflurane, apoptosis, hippocampus, signal pathway, review

中图分类号:

R614

参考文献 36

[1]	CHEN X, ZHOU X, YANG L, et al. Neonatal exposure to low-dose(1.2%)sevoflurane increases rats' hippocampal neurogenesis and synaptic plasticity in later life[J]. Neurotox Res, 2018, 34(2):188-197. doi: 10.1007/s12640-018-9877-3.
[2]	ZUO Y, CHANG Y, THIRUPATHI A, et al. Prenatal sevoflurane exposure:Effects of iron metabolic dysfunction on offspring cognition and potential mechanism[J]. Int J Dev Neurosci, 2021, 81(1):1-9. doi: 10.1002/jdn.10080.
[3]	YU Q, DAI H, JIANG Y, et al. Sevoflurane alleviates oxygen-glucose deprivation/reoxygenation-induced injury in HT22 cells through regulation of the PI3K/AKT/GSK3β signaling pathway[J]. Exp Ther Med, 202, 21(4):376. doi: 10.3892/etm.2021.9807.
[4]	YANG Z, YUAN C. IL-17A promotes the neuroinflammation and cognitive function in sevoflurane anesthetized aged rats via activation of NF-κB signaling pathway[J]. BMC Anesthesiol, 2018, 18(1):147. doi: 10.1186/s12871-018-0607-4.
[5]	SHARMA V K, SINGH T, SINGH S, et al. Apoptotic pathways and alzheimer's disease:probing therapeutic potential[J]. Neurochem Res, 2021, 46(12):3103-3122. doi: 10.1007/s11064-021-03418-7.
[6]	VIGNESWARA V, AHMED Z. The role of Caspase-2 in regulating cell fate[J]. Cells, 2020, 9(5):1259. doi: 10.3390/cells9051259.
[7]	OBENG E. Apoptosis(programmed cell death)and its signals - A review[J]. Braz J Biol, 2021, 81(4):1133-1143. doi: 10.1590/1519-6984.228437.
[8]	LI M, GUO J, WANG H, et al. Involvement of mitochondrial dynamics and mitophagy in sevoflurane-Induced cell toxicity[J]. Oxid Med Cell Longev, 2021, 2021:6685468. doi: 10.1155/2021/6685468.
[9]	MIRZAYANS R, ANDRAIS B, KUMAR P, et al. The growing complexity of cancer cell response to DNA-damaging agents:caspase 3 mediates cell death or survival?[J]. Int J Mol Sci, 2016, 17(5):708. doi: 10.3390/ijms17050708.
[10]	KASHYAP D, GARG V K, GOEL N. Intrinsic and extrinsic pathways of apoptosis:Role in cancer development and prognosis[J]. Adv Protein Chem Struct Biol, 2021, 125:73-120. doi: 10.1016/bs.apcsb.2021.01.003.
[11]	TANG W, WANG W, ZHANG Y, et al. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced chemokine release in both TRAIL-resistant and TRAIL-sensitive cells via nuclear factor kappa B[J]. FEBS J, 2009, 276(2):581-593. doi: 10.1111/j.1742-4658.2008.06809.x.
[12]	魏海婷, 任峰, 刘琳琳, 等. TLR4-p38MAPK-NF-κB信号通路在七氟醚降低老龄大鼠认知功能中的作用[J]. 中华麻醉学杂志, 2019, 39(5):561-564.
	WEI H T, REN F, LIU L L, et al. Role of TLR4-p38MAPK-NF-κB signaling pathway in sevoflurane-induced decrease in cognitive function of aged rats[J]. Chin J Anesthesiol, 2019, 39(5):561-564. doi: 10.3760/cma.j.issn.0254-1416.2019. 05.013.
[13]	MAO J, HU Y, RUAN L, et al. Role of endoplasmic reticulum stress in depression (Review)[J]. Mol Med Rep, 2019, 20(6):4774-4780. doi: 10.3892/mmr.2019.10789.
[14]	HAN Y, YUAN M, GUO Y S, et al. Mechanism of endoplasmic reticulum stress in cerebral ischemia[J]. Front Cell Neurosci, 2021, 15:704334. doi: 10.3389/fncel.2021.704334.
[15]	LIU R, CHEN Y, LIU G, et al. PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers[J]. Cell Death Dis, 2020, 11(9):797. doi: 10.1038/s41419-020-02998-6.
[16]	SU R, SUN P, ZHANG D, et al. Neuroprotective effect of miR-410-3p against sevoflurane anesthesia-induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C-X-C motif chemokine receptor 5[J]. Genes Genomics, 2019, 41(10):1223-1231. doi: 10.1007/s13258-019-00851-5.
[17]	YANG L H, XU Y C, ZHANG W. Neuroprotective effect of CTRP3 overexpression against sevoflurane anesthesia-induced cognitive dysfunction in aged rats through activating AMPK/SIRT1 and PI3K/AKT signaling pathways[J]. Eur Rev Med Pharmacol Sci, 2020, 24(9):5091-5100. doi: 10.26355/eurrev_202005_21202.
[18]	TIAN Y, GUO S, WU X, et al. Minocycline alleviates sevoflurane-induced cognitive impairment in aged rats[J]. Cell Mol Neurobiol, 2015, 35(4):585-594. doi: 10.1007/s10571-014-0154-6.
[19]	HEPWORTH E, HINTON S D. Pseudophosphatases as regulators of MAPK signaling[J]. Int J Mol Sci, 2021, 22(22):12595. doi: 10.3390/ijms222212595.
[20]	YUE J, LÓPEZ J M. Understanding MAPK signaling pathways in apoptosis[J]. Int J Mol Sci, 2020, 21(7):2346. doi: 10.3390/ijms21072346.
[21]	WANG W W, JIA L J, LUO Y, et al. Location- and subunit-specific NMDA receptors determine the developmental sevoflurane neurotoxicity through ERK1/2 signaling[J]. Mol Neurobiol, 2016, 53(1):216-230. doi: 10.1007/s12035-014-9005-1.
[22]	LIU T, DONG X, WANG B, et al. Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats[J]. Cell Cycle, 2020, 19(6):684-696. doi: 10.1080/15384101.2020.1717041.
[23]	SONG H, XUN S, HE H, et al. Compound porcine cerebroside and ganglioside Injection (CPCGI) attenuates sevoflurane-induced nerve cell injury by regulating the phosphorylation of p38 MAP kinase (p38MAPK)/nuclear factor kappa B(NF-κB)pathway[J]. Med Sci Monit, 2020, 26:e919600. doi: 10.12659/MSM.919600.
[24]	BI C, CAI Q, SHAN Y, et al. Sevoflurane induces neurotoxicity in the developing rat hippocampus by upregulating connexin 43 via the JNK/c-Jun/AP-1 pathway[J]. Biomed Pharmacother, 2018, 108:1469-1476. doi: 10.1016/j.biopha.2018.09.111.
[25]	HANG P Z, GE F Q, LI P F, et al. The regulatory role of the BDNF/TrkB pathway in organ and tissue fibrosis[J]. Histol Histopathol, 2021, 36(11):1133-1143. doi: 10.14670/HH-18-368.
[26]	ZHANG D, XUE B, YOU J, et al. Suberoylanilide hydroxamic acid reversed cognitive and synaptic plasticity impairments induced by sevoflurane exposure in adult mice[J]. Neuroreport, 2019, 30(4):274-279. doi: 10.1097/WNR.0000000000001196.
[27]	ZHANG T, GUO Q, ZOU W, et al. Neonatal isoflurane exposure induces neurocognitive impairment and abnormal hippocampal histone acetylation in mice[J]. PLoS One, 2015, 10(4): e0125815. doi: 10.1371/journal.pone.0125815
[28]	JIA J, ZHU J, YANG Q, et al. The role of histone acetylation in the sevoflurane-induced Inhibition of neurogenesis in the hippocampi of young mice[J]. Neuroscience, 2020, 432:73-83. doi: 10.1016/j.neuroscience.2020.02.023.
[29]	XU Z, QIAN B. Sevoflurane anesthesia-mediated oxidative stress and cognitive impairment in hippocampal neurons of old rats can be ameliorated by expression of brain derived neurotrophic factor[J]. Neurosci Lett, 2020, 721:134785. doi: 10.1016/j.neulet.2020.134785.
[30]	LIU C Y, ZHOU Y, CHEN T, et al. AMPK/SIRT1 pathway is involved in arctigenin-mediated protective effects against myocardial ischemia-reperfusion injury[J]. Front Pharmacol, 2021, 11:616813. doi: 10.3389/fphar.2020.616813.
[31]	YANG X Y, LI Q J, ZHANG W C, et al. AMPK-SIRT1-PGC1α signal pathway influences the cognitive function of aged rats in sevoflurane-induced anesthesia[J]. J Mol Neurosci, 2020, 70(12):2058-2067. doi: 10.1007/s12031-020-01612-w.
[32]	LIU L, LIU C, FANG L. AMPK‑SIRT1 pathway dysfunction contributes to neuron apoptosis and cognitive impairment induced by sevoflurane[J]. Mol Med Rep, 2021, 23(1):56. doi: 10.3892/mmr.2020.11694.
[33]	YANG X, YANG S, HONG C, et al. Panax notoginseng saponins attenuates sevoflurane‑induced nerve cell injury by modulating AKT signaling pathway[J]. Mol Med Rep, 2017, 16(5):7829-7834. doi: 10.3892/mmr.2017.7519.
[34]	WANG Y, WANG C, ZHANG Y, et al. Pre-administration of luteoline attenuates neonatal sevoflurane-induced neurotoxicity in mice[J]. Acta Histochem, 2019, 121(4):500-507. doi: 10.1016/j.acthis.2019.04.004.
[35]	康文越, 邢丹丹, 付强, 等. 右美托咪定通过p38通路改善发育期大鼠七氟醚麻醉后认知功能障碍[J]. 中国免疫学杂志, 2020, 36(9):1091-1096.
	KANG W Y, XING D D, FU Q, et al. Dexmedetomidine improves cognitive dysfunction after sevoflurane anesthesia in developing rats through p38 pathway[J]. Chinese Journal of Immunology, 2020, 36(9):1091-1096. doi: 10.3969/j.issn.1000-484X.2020.09.013.
[36]	YUE H, HU B, LUO Z, et al. Metformin protects against sevoflurane-induced neuronal apoptosis through the S1P1 and ERK signaling pathways[J]. Exp Ther Med, 2019, 17(2):1463-1469. doi: 10.3892/etm.2018.7098.

七氟烷对海马神经元凋亡相关信号通路影响的研究进展

Research progress on effects of sevoflurane on apoptosis related signal pathways of hippocampal neurons

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