摘要： Objective To investigate the efficacy and safety of intensive antihypertensive therapy and standard antihypertensive therapy after percutaneous coronary intervention (PCI) in elderly hypertensive patients with coronary heart disease. Methods A total of 86 elderly patients with hypertension complicated with coronary heart disease were randomly divided into the control group and the study group with 43 cases in each group. The control group was given standard antihypertensive therapy [target systolic blood pressure (SBP)<135 mmHg], and the study group was given intensive antihypertensive therapy target SBP<120 mmHg). Follow-up was conducted for 12 months from the beginning of treatment. The variation rate of blood pressure before and after treatment was recorded by wearing a home blood pressure monitor. Color Doppler ultrasound was used to evaluate the cardiac function indexes before and after treatment. The visual analogue scale of the European Five-Dimensional Health Assessment Scale (EQ-5D-3L) was used to evaluate the health status of patients. The patient Health Questionnaire Depression Scale (PHQ-9) was used to evaluate the depression mood of the patients. The Self-rating Anxiety Scale (SAS) was used to evaluate anxiety mood, and the fall Efficacy Scale International version (FES-I) was used to evaluate fall risk. Results There were no significant differences in 24 h SBP and 24 h diastolic blood pressure (DBP) coefficient of variation, left ventricular ejection fraction (LVEF), left ventricular mass index (LVMI), left atrial volume index (LAVI), EQ-5D-3L score, PHQ-9 score, SAS score and FES-I score before treatment between the two groups (P>0.05). The coefficients of variation of 24 h SBP and 24 h DBP were lower in the study group than those in the control group (P<0.05). Data of LVEF, LVMI and EQ-5D-3L were higher in the study group than those in the control group (P<0.05). LAVI, PHQ-9, SAS and FES-I were lower than those in the control group (P<0.05). There was no significant difference in the incidence of total adverse reactions between the study group and the control group (P>0.05). The total incidence of new cardiovascular and cerebrovascular events were lower in the study group than those in the control group (P<0.05). Conclusion Intensive antihypertensive therapy is better than standard antihypertensive therapy in controlling blood pressure (24 h) rhythm variability and cardiac function after PCI in elderly hypertensive patients with coronary heart disease and can reduce the risk of cardiovascular and cerebrovascular adverse events, improve the quality of life with good safety.

中图分类号: 

• R544.1