摘要： Objective To investigate the relationship between serum complement- C1q/TNF related protein 1 (CTRP1), CTRP5 and ratio of CTRP1 to CTRP5 (CTRP1/CTRP5) and unstable angina pectoris (UAP). Methods A total of 103 patients with UAP were selected as subjects. Patients were divided into the mild coronary stenosis group (GS≤39, n=53) and the severe coronary stenosis group (GS>39, n=50) according to the median of Gensini (GS) score. Patients were divided into the single-vessel lesion group (n=20), the double-vessel lesion group (n=46) and the multi-vessel lesion group (n=37), according to the number of coronary artery lesions. Forty-seven patients with cardiac neurosis whose coronary stenosis was less than 50% were selected as the control group. Enzyme linked immunosorbent assay was used to detect serum levels of CTRP1 and CTRP5, and then the level of CTRP1/CTRP5 was calculated. Results The levels of CTRP1, CTRP5 and CTRP1/CTRP5 were higher in the UAP group than those in the control group (P<0.05). The levels of CTRP1 and CTRP5 were higher in the severe coronary stenosis group than those of the mild coronary stenosis group (P<0.05). The level of CTRP1 was higher in the multi-vessel lesion group than that in the single-vessel lesion group among UAP with different vascular lesions (P<0.05). Results of multivariate Logistic analysis showed that CTRP1 was an independent predictor of UAP. ROC curve analysis showed that the area under the ROC curve (AUC) of serum CTRP1, CTRP5 and CTRP1/CTRP5 for UAP assisted screening were 0.757, 0.631 and 0.625, and the cut-off values were 870.33 μg/L, 43.04 μg/L and 18.41, respectively. The sensitivity of CTRP1/CTRP5 was higher (84.5%), and the specificity of CTRP1 was higher (78.7%). Conclusion CTRP1 and CTRP5 are involved in the occurrence and development of UAP. Detection of serum levels of CTRP1 and CTRP5 and calculation of CTRP1/CTRP5 levels are helpful for UAP screening and disease assessment.

中图分类号: 

• R541.42，R446.112