孟德尔随机化在便秘病因探索中的研究进展

doi:10.11958/20260765

天津医药 ›› 2026, Vol. 54 ›› Issue (10): 1110-1114.doi: 10.11958/20260765

孟德尔随机化在便秘病因探索中的研究进展

王彦龙¹(), 梁磊², 刘仕鸿¹, 何德才¹^,^△()

¹ 川北医学院附属医院中西医结合肛肠科（邮编 637000）
² 天津中医药大学研究生院

收稿日期:2026-03-21 修回日期:2026-04-16 出版日期:2026-10-15 发布日期:2026-10-10
通讯作者: △E-mail：hdc9706@sohu.com
作者简介:王彦龙（1999），男，硕士在读，主要从事中西医结合防治肛肠疾病方面研究。E-mail：1070580533@qq.com
基金资助:
四川省中西医结合学会科研专项课题(ZXY2025024);天津市名中医传承工作室建设项目(津卫中[2024]61号)

Research progress of Mendelian randomization in investigating the etiology of constipation

WANG Yanlong¹(), LIANG Lei², LIU Shihong¹, HE Decai¹^,^△()

¹ Department of Integrated Traditional Chinese and Western Medicine Proctology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
² Graduate School of Tianjin University of Traditional Chinese Medicine

Received:2026-03-21 Revised:2026-04-16 Published:2026-10-15 Online:2026-10-10
Contact: △E-mail：hdc9706@sohu.com

王彦龙, 梁磊, 刘仕鸿, 何德才. 孟德尔随机化在便秘病因探索中的研究进展[J]. 天津医药, 2026, 54(10): 1110-1114.

WANG Yanlong, LIANG Lei, LIU Shihong, HE Decai. Research progress of Mendelian randomization in investigating the etiology of constipation[J]. Tianjin Medical Journal, 2026, 54(10): 1110-1114.

摘要/Abstract

摘要：

便秘是临床常见的慢性功能性或器质性肠疾病，其病因存在显著异质性。传统病因学研究易受混杂因素、反向因果及临床实施可行性等影响，难以准确揭示危险因素与便秘之间的真实因果关联。孟德尔随机化（MR）以遗传变异为工具变量，为便秘病因探索提供了新的研究思路。该文从患者生活方式、与多系统疾病的关联、肠道菌群及循环代谢物等方面，对MR与便秘的潜在因果关联进行综述。

关键词: 孟德尔随机化分析, 便秘, 因果律, 遗传变异, 胃肠道微生物组

Abstract:

Constipation is a common chronic functional or organic intestinal disease in clinical practice with significant heterogeneity in its etiology, and it has become an important factor contributing to the global disease burden. Traditional etiological studies are easily affected by confounding factors, reverse causality and clinical feasibility, making it difficult to accurately reveal the true causal relationship between risk factors and constipation. Mendelian randomization (MR), which uses genetic variations as instrumental variables, provides a new research idea for exploring the etiology of constipation. This article reviews the potential causal relationship between MR and constipation from aspects such as lifestyle, association with multiple system diseases, intestinal flora and circulating metabolites.

Key words: Mendelian randomization analysis, constipation, causality, genetic variation, gastrointestinal microbiome

中图分类号:

R574.62

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孟德尔随机化在便秘病因探索中的研究进展

Research progress of Mendelian randomization in investigating the etiology of constipation

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