子宫内膜疾病与生殖道菌群及肠道菌群串扰的研究进展

doi:10.11958/20252544

天津医药 ›› 2026, Vol. 54 ›› Issue (2): 127-131.doi: 10.11958/20252544

• 专题研究·生殖系统疾病 • 上一篇下一篇

子宫内膜疾病与生殖道菌群及肠道菌群串扰的研究进展

董昀澍(), 潘恒, 牛红娟()

北京大学第三医院生殖医学中心，国家妇产疾病临床医学研究中心，辅助生殖教育部重点实验室，北京市生殖内分泌与辅助生殖技术重点实验室（邮编100191）

收稿日期:2025-08-01 修回日期:2025-10-21 出版日期:2026-02-15 发布日期:2026-02-12
通讯作者: 牛红娟 E-mail:ysdong1125@163.com;niuhongjuan1@163.com
作者简介:董昀澍（1992），女，博士在读，主要从事生殖医学方面研究。E-mail：ysdong1125@163.com
基金资助:
国家重点研发计划项目(2022YFC2702501)

Research progress on the interaction between endometrial diseases and the microbiota of reproductive and gastrointestinal tracts

DONG Yunshu(), PAN Heng, NIU Hongjuan()

Center for Reproductive Medicine, Peking University Third Hospital; National Clinical Research Center for Obstetrics and Gynecology; Key Laboratory of Assisted Reproduction, Ministry of Education; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing 100191, China

Received:2025-08-01 Revised:2025-10-21 Published:2026-02-15 Online:2026-02-12
Contact: NIU Hongjuan E-mail:ysdong1125@163.com;niuhongjuan1@163.com

董昀澍, 潘恒, 牛红娟. 子宫内膜疾病与生殖道菌群及肠道菌群串扰的研究进展[J]. 天津医药, 2026, 54(2): 127-131.

DONG Yunshu, PAN Heng, NIU Hongjuan. Research progress on the interaction between endometrial diseases and the microbiota of reproductive and gastrointestinal tracts[J]. Tianjin Medical Journal, 2026, 54(2): 127-131.

摘要/Abstract

摘要：

子宫内膜异位症、子宫内膜癌和慢性子宫内膜炎等子宫内膜疾病的病理机制复杂。肠道菌群作为人体最重要的微生态系统，在物质代谢、免疫调节及神经内分泌调控等方面发挥关键作用，而女性生殖道菌群的稳态已被证实是维持生殖健康的基础。“肠-器官轴”理论的兴起推动了对肠道与生殖道菌群间微生态相互作用的关注。该文基于文献计量学方法，系统梳理肠道与生殖道菌群在子宫内膜疾病发生发展中的串扰机制，探讨关键功能菌群及相关调控通路，并展望从微生态理论向临床转化应用的潜在策略。

关键词: 子宫疾病, 子宫内膜, 胃肠道微生物组, 生殖道菌群

Abstract:

Pathological mechanisms of endometrial disorders, including endometriosis, endometrial carcinoma and chronic endometritis are complex. The intestinal flora, as the most important micro-ecosystem in human body, plays a key role in material metabolism, immune regulation and neuroendocrine control. The homeostasis of the female reproductive tract microbiota has been proven to be the foundation for maintaining reproductive health. The "gut-organ axis" theory has driven attention to microecological interaction between the intestinal and reproductive tract microbiota. This review surveys current microecological research on the interplay between endometrial pathologies and alterations, and systematically sorts out the crosstalk mechanism of intestinal and reproductive tract microbiota in occurrence and development of endometrial diseases. Finally, the article explores the key functional microbiota and related regulatory pathways, and looks forward to the potential strategies for the transformation and application from microecological theory to clinical practice.

Key words: uterine diseases, endometrium, gastrointestinal microbiome, genital microbiota

中图分类号:

R711.74

图/表 2

参考文献 37

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子宫内膜疾病与生殖道菌群及肠道菌群串扰的研究进展

Research progress on the interaction between endometrial diseases and the microbiota of reproductive and gastrointestinal tracts

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