天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (1): 99-103.doi: 10.11958/20171003

• 综述 • 上一篇    下一篇

血小板活化信号转导机制研究进展

卞敬琦，冯月男，牛雯颖，肖洪彬△   

  1. 黑龙江中医药大学（邮编 150040）
  • 收稿日期:2017-10-09 修回日期:2017-11-17 出版日期:2018-01-15 发布日期:2018-01-16
  • 通讯作者: 肖洪彬 E-mail:jiafeimao19860405@163.com
  • 作者简介:卞敬琦（1986），女，博士在读，主要从事药理学研究
  • 基金资助:
    基于血小板活化的血瘀模型生物学特征探讨及方证相关研究

Advances in signal transduction pathway of platelet activation

BIAN Jing-qi, FENG Yue-nan, NIU Wen-ying, XIAO Hong-bin△   

  1. Heilongjiang University of Chinese Medicine, Heilongjiang 150040, China
  • Received:2017-10-09 Revised:2017-11-17 Published:2018-01-15 Online:2018-01-16

PDF (PC)

4019

摘要： 血小板是哺乳动物血液中固有成分之一，在止血、炎性反应、血栓形成以及器官移植排斥等生理与病理反 应中具有重要作用。血小板活化信号是激活、诱导血小板发挥生理作用的主要生理传导机制，一直是近年来生理学 领域研究的重点。本文将就黏附受体介导的钙离子水平调节新机制、模式识别受体诱导的血小板活化新观点以及 血小板环鸟苷酸信号通路新概念等方面作一综述。

关键词: 血小板活化, 信号传导, 综述

Abstract: Platelets are one of essential components of mammalian blood and play an important role in physiological and pathological reactions such as hemostasis, inflammatory response, thrombosis and rejection of organ transplantation. Platelet activation signal is the main physiological transmission mechanism that activates and induces platelets to play a physiological role, which has been the research focus in the field of physiological research in recent years. In this paper, we reviewed the new mechanisms of adhesion receptor-mediated calcium elevation, the new ideas of platelet activation mediated by pattern recognition receptors, and the new concept in platelet cGMP signaling and some other new researches.

Key words: platelet activation, signal transduction, review