天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (6): 606-609.doi: 10.11958/20180453

• 专题研究·重症医学-综述 • 上一篇    下一篇

脓毒症相关性血小板减少发病机制的研究现状

许华，王兵，王勇强   

  1. 天津市第一中心医院重症医学科（邮编300192）
  • 收稿日期:2018-03-27 修回日期:2018-04-18 出版日期:2018-06-15 发布日期:2018-07-05
  • 通讯作者: 王勇强 E-mail:yongqiangwang1962@sina.com

The research status of pathogenesis of sepsis related thrombocytopenia

XU Hua, WANG Bing, WANG Yong-qiang   

  1. Department of Critical Care Medicine, Tianjin First Center Hospital, Tianjin 300192, China
  • Received:2018-03-27 Revised:2018-04-18 Published:2018-06-15 Online:2018-07-05
  • Contact: WANG Yongqiang E-mail:yongqiangwang1962@sina.com

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摘要： 脓毒症是由感染引起的反应失调而出现致死性的器官功能障碍。血小板减少不仅是其常见并发症，而且与患者的预后具有相关性。在临床治疗中，明确脓毒症相关性血小板减少的病因病机，选择适当的方法及时纠正血小板减少对患者预后的改善具有极其重要的意义。现就脓毒症相关性血小板减少的病因、病生理机制及分子机制的研究现状进行综述。

关键词: 脓毒症, 血小板减少, 病因, 病理生理机制, 分子机制

Abstract: Sepsis is a lethal organ dysfunction caused by infection induced reaction maladjustment. Thrombocytopenia is not only a common complication of sepsis, but also closely related to the patient's prognosis. In the clinical treatment, it is important to identify the etiology and pathogenesis of thrombocytopenia associated with sepsis and choose appropriate methods to correct thrombocytopenia in time to improve the prognosis of patients. This article gives an introduction to the research status of the etiology, pathophysiological mechanism and molecular mechanism of sepsis-related thrombocytopenia.

Key words: sepsis, thrombocytopenia, pathogen, pathophysiological mechanisms, molecular mechanism