天津医药 ›› 2019, Vol. 47 ›› Issue (4): 339-342.doi: 10.11958/20190525

• 专题研究·胆道闭锁与肝移植 • 上一篇    下一篇

病毒疫苗对预防胆道闭锁的可行性探讨

詹江华 1△,余晨 2   

  1. 1天津市儿童医院小儿外科(邮编 300134);2天津医科大学研究生院
  • 收稿日期:2019-02-26 修回日期:2019-03-19 出版日期:2019-04-15 发布日期:2019-05-27
  • 通讯作者: 詹江华 E-mail:zhanjianghuatj@163.com
  • 作者简介:詹江华(1963),男,博士,主任医师,教授,博士生导师,主要从事胆道闭锁方面研究
  • 基金资助:
    胆道闭锁序贯性治疗;胆道闭锁肝纤维化中TGF-β信号通路机制研究

Feasibility of viral vaccine in preventing biliary atresia

ZHAN Jiang-hua1△, YU Chen2   

  1. 1 Department of Pediatric Surgery, Tianjin Children’s Hospital, Tianjin 300134, China; 2 Graduate School of Tianjin Medical University
  • Received:2019-02-26 Revised:2019-03-19 Published:2019-04-15 Online:2019-05-27
  • Contact: zhanjianghua E-mail:zhanjianghuatj@163.com

摘要: 胆道闭锁(BA)是引起新生儿梗阻性黄疸的常见原因,也是导致肝脏功能衰竭的严重的肝胆系统疾病。目 前关于 BA的病因及发病机制的研究还在继续,但种种迹象表明,围生期病毒感染在 BA的发生发展中扮演着重要角 色,有可能是引起 BA的真正原因。本文主要从病毒疫苗接种的角度出发,探讨其对预防 BA的可行性,以期为降低 BA的发病率提供一个全新的视角。

关键词: 胆道闭锁, 巨细胞病毒, 轮状病毒属, 疱疹病毒 4型, 人, 呼肠病毒科, 疫苗

Abstract: Biliary atresia (BA) is a common cause of obstructive jaundice in the infantile period, and also a severe hepatobiliary disease leading to liver failure. At present, the research on the etiology and pathogenesis of BA is continuing. But various signs show that perinatal viral infection plays an important role in the occurrence and development of BA, which may be the exact cause of BA. Therefore, this paper mainly discussed the feasibility of preventing BA from the view of virus vaccination, in order to provide a new perspective for reducing the incidence of BA.

Key words: biliary atresia, cytomegalovirus, rotavirus, herpesvirus 4, human, reoviridae, vaccines